The aim of this study was to determine if the compressive strength of a macroporous biphasic calcium phosphate ceramic (MBCP) changed with post-implantation physicochemical transformations, in the absence of true bone deposition. MBCP cylinders were implanted in rabbit femurs and muscles. Compressive strength measurements and Fourier transform infrared (FTIR) spectroscopy measurements were performed after 1,2,3,6 and 12 weeks. MBCP blocks implanted in a human and removed after 1 week due to a clinical problem were also submitted to the same analyses. Results showed that compressive strength increased in both osseous and muscular sites. Mechanical improvement was also measured on MBCP implanted in a human. Physico-chemical changes, particularly biological apatite precipitations, were evident in MBCP implanted in muscle and in a human. This study has shown that the compressive strength of MBCP increased after implantation, even in the absence of true bone deposition. This suggests that in vivo physico-chemical processes could improve the mechanical properties of MBCP.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. Jarcho, Clin. Orthop. Rel. Res. 157 (1981) 259.
N. Passuti, G. Daculsi, J. M. Rogez, S. Martin and J. V. Bainvel, Clin. Orthop. Rel. Res. 248 (1989) 169.
D. C. Moore, M. W. Chapman and D. Manske, J. Orthop. Res. 5 (1987) 356.
K.De Groot, Biomaterials 1 (1980) 47.
G. Daculsi, R. Z. Legeros, E. Nery, K. Lynch and B. Kerebel, J. Biomed. Mater. Res. 23 (1989) 883.
G. Daculsi, R. Z. Legeros, M. Heughebaert and I. Barbieux, Calcif. Tissue 46 (1990) 20.
R. B. Martin, M. W. Chapman, N. A. Sharkey, S. L. Zissimos, B. Bay and E. C. Shors, Biomaterials 14 (1993) 341.
R. B. Martin, M. W. Chapman, R. E. Holmes, D. J. Sartoris, E. C. mShors, J. E. Gordon, D. O. Heitter, N. A. Sharkey and A. G. Zissimos, Biomaterials 10 (1989) 481.
M. Trecant, J. Delecrin, J. Royer, E. Goyen-Valle and G. Daculsi, Clin. Mater. 15 (1994) 233.
R. Z. Legeros, J. P. Legeros, O. R. Trautz and E. Klein, Dev. Appl. Spectrosc. 7B (1970) 3.
D. J. McCarty, J. R. Lehr and P. B. Halverson, Arth. Rheum. 10 (1983) 1220.
M. A. Walters, Y. C. Leung, N. C. Blumenthal, R. Z. Legeros and K. A. Konsker, Inorg. Biochem 39 (1990) 193.
G. Daculsi, N. Passuti, S. Martin, C. Deudon, R. Z. Legeros and S. Raher, J. Biomed. Mater. Res. 24 (1990) 379.
R. Z. Legeros, G. Daculsi, I. Orly, M. Gregoire, M. Heughebaert, M. Gineste and R. Kijkowska, in “Bone-bonding-Reed Healthcare Communications” (Ducheyne, Kokubo & Van Blitterswijk, Leiderdop 1992) p. 201.
M. Heughebaert, R. Z. Legeros, M. Gineste, A. Guilhem and B. Bonel, J. Biomed. Mater. Res. 22 (1988) 257.
Author information
Authors and Affiliations
Additional information
This paper was accepted for publication after the 1995 Conference of the European Society of Biomaterials, Oporto, Portugal, 10–13 September.
Rights and permissions
About this article
Cite this article
Trecant, M., Delecrin, J., Nguyen, J.M. et al. Influence of post-implantation physico-chemical changes in a macroporous ceramic on its mechanical strength. J Mater Sci: Mater Med 7, 227–229 (1996). https://doi.org/10.1007/BF00119735
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00119735