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Evaluation of malondialdehyde as an index of lead damage in rat brain homogenates

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Abstract

Lipid peroxidation in vitro homogenates of brain was examined as sequela of lead toxicity. The levels of malondialdehyde (MDA) in homogenates of rat brain (1 ml, 5% w/v) treated with lead (50 μg) alone or in combination with ascorbic acid (100 μg), alphatocopherol (100 μg) or hydroquinone (100 μg) were evaluated. The levels of MDA were consistently evoked by lead in a dose-related manner. The toxicity of lead was further advanced by the action of the pro-oxidant drug ascorbic acid on the brain. However, the anti-oxidant drugs alphatocopherol and hydroquinone decreased the toxic effect of lead on the brain. These results clearly show that the enhanced lipid peroxidation may provide a basis of lead-induced neurotoxicity.

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Authors and Affiliations

  1. Department of Pharmacology, J. N. Medical College. Muslim University, Aligarh, India

    Shafiq-ur-Rehman, Shaheen Rehman & Om Chandra

  2. Department of Clinical Chemistry, University Hospital, Lund, Sweden

    Mohammad Abdulla

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  1. Shafiq-ur-Rehman
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  2. Shaheen Rehman
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  3. Om Chandra
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  4. Mohammad Abdulla
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Shafiq-ur-Rehman, Rehman, S., Chandra, O. et al. Evaluation of malondialdehyde as an index of lead damage in rat brain homogenates. Biometals 8, 275–279 (1995). https://doi.org/10.1007/BF00141599

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  • DOI: https://doi.org/10.1007/BF00141599

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