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Some new aspects of CJD epidemiology in Slovakia

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Abstract

Descriptive epidemiological and genealogical data obtained by prospective and retrospective studies on CJD in Slovakia and in patients emigrating from CJD clusters were analysed.

Observations contradictory to an exclusively genetic etiology of temporo-spatial accumulation of CJD are presented. Data indicating a genetically increased susceptibility to the disease and its coincidence with environmental risk in clustering patients are discussed.

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References

  1. ArayaG., GalvezS., CartierL. and GajdusekD.C. (1983): A spatio temporal clustering of Creutzfeldt-Jakob disease in Chile - Rev. Chil. Neuropsiquiqt. 21: 291–195.

    Google Scholar 

  2. Brown P. and Cathala F. (1979): Creutzfeldt-Jakob disease in France. In: Prusiner S., Hadlow W. - Eds. Slow transmissible diseases of the nervous system -Vol. l. NY Acad Press, 213–227.

  3. BrownP., CathalaF., RaubertasR. et al. (1987): The epidemiology of Creutzfeldt-Jakob disease: conclusion of a 15-year investigation in France -Neurology, 37: 895–904.

    Google Scholar 

  4. GoldfarbL., MitrovaE., BrownP., TohB. and GajdusekD. (1990): Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia - Lancet, 33: 514.

    Google Scholar 

  5. Goldfarb L., Brown P., Mitrova E., Cervenakova L. et al. (1991): Creutzfeldt-Jakob disease with the PRNP codon 200 Lys mutation : an analysis of 45 families. Europ. J. Epidemiol. This issue.

  6. MastersC., HarrisJ., GajdusekD.C. et al. (1979): Creutzfeldt-Jakob disease: pattern of worldwide occurrence and the significance of familial and sporadic clustering - Ann Neurol. 5: 177–188.

    Google Scholar 

  7. MitrovaE. and MayerV. (1981): Inherited susceptibility, Ovine brain consumption and Creutzfeldt-Jakob disease - J. Neurol. 226: 219–220.

    Google Scholar 

  8. MitrovaE., LowenthalA. and AppealB. (1990): Familial Creutzfeldt-Jakob disease with temporal and spatial separation of affected members - Europ. J. Epidemiol. 6: 3 233–238.

    Google Scholar 

  9. Mitrova E. and Bronis M. (1991): Cluster of CJD in Slovakia: The first statistically significant temporospatial accumulation of patients - Europ J. Epidemiol., This issue.

  10. Mitrova E., Huncaga S., Hocman G., Nyitrayova O., Tatara M. and Cervenakova L. (1991): Cluster of CJD in Slovakia: The first laboratory evidence of scrapie -Europ. J. Epidemiol., This issue.

  11. NeugutR., NeugutA., KahanaE et al. (1979): Creutzfeldt-Jakob disease: familial clustering among Libyan-born Israelis - Neurology 29: 225–231.

    Google Scholar 

  12. WillR., MathewsW., SmithP. et al. (1986): A retrospctive study of Creutzfeldt-Jakob disease in England and Wales 1970–1979 - J. Neurol. Neurosur. Psych., 49: 749–755.

    Google Scholar 

  13. ZlamalV. (1987): Allatkor es gyogytan - Budapest, Atheneum Kiado, pp. 285.

    Google Scholar 

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Mitrova, E. Some new aspects of CJD epidemiology in Slovakia. Eur J Epidemiol 7, 439–449 (1991). https://doi.org/10.1007/BF00143119

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