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Pattern electroretinogram in glaucoma and ocular hypertension

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Abstract

We recorded the pattern electroretinogram (PERG) to small (0.8°) and very large (15°) check sizes in normal subjects, in patients with early-stage glaucoma, and in patients with ocular hypertension. In glaucoma, the PERG amplitude was reduced. This reduction was more prominent for a check size of 0.8° as compared with 15° stimuli and for high (16/s) as compared with low (7.8/s) reversal rates. Using a discriminant analysis of the amplitudes for two different check sizes, we could distinguish the normal and the glaucoma groups with a specificity of 96% and a sensitivity of 91%. Of the ocular hypertension patients, 43% were classified as pathologic by the discriminant analysis. Thus multivariate analysis of the PERG may increase its diagnostic value.

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References

  1. Groneberg, A., Taping, C. 1980. Topodiagnostik von Sehstörungen durch Ableitung retinaler und kortikaler Antworten auf Umkehr-Kontrastmuster. Ber. Dtsch. Ophthalmol. Ges. 77: 409–15.

    Google Scholar 

  2. Maffei, L., Fiorentini, A. 1981. Electroretinographic responses to alternating gratings before and after section of the optic nerve. Science 211: 953–5.

    Google Scholar 

  3. Bach, M., Hiss, P., Röver, J. 1988. Pattern-ERG to luminance stimuli in normals and patients with optic atrophy. Fortschr. Ophthalmol. 85: 308–11.

    Google Scholar 

  4. Wanger, P., Persson, H.E. 1985. Pattern-reversal electroretinograms in ocular hypertension. Doc. Ophthalmol. 61: 27–31.

    Google Scholar 

  5. Porciatti, V., Falsini, B., Brunori, S., Colotto, A., Moretti, G. 1987. Pattern electroretinogram as a function of spatial frequency in ocular hypertension and early glaucoma. Doc. Ophthalmol. 65: 349–55.

    Google Scholar 

  6. Papst, N., Bopp, M., Schnaudigel, O.E. 1984. The pattern evoked electroretinogram associated with elevated intraocular pressure. Graefe's Arch. Clin. Exp. Ophthalmol. 222: 34–7.

    Google Scholar 

  7. Wanger, P., Persson, H.E. 1987. Pattern-reversal electroretinograms and high-pass resolution perimetry in suspected or early glaucoma. Ophthalmoloy. 94: 1098–1103.

    Google Scholar 

  8. Trick, G.L. 1987. Pattern reversal retinal potentials in ocular hypertensives at high and low risk of developing glaucoma. Doc. Ophthalmol. 65: 79–85.

    Google Scholar 

  9. Bach, M., Hiss., P., Röver, J. 1988. Check size specific changes of pattern-ERG in patients with early stages of open-angle glaucoma. Doc. Ophthalmol. 69: 315–22.

    Google Scholar 

  10. Atkin, A., Bodis-Wollner, I., Wolkstein, M., Moss, A., Podos, S.M. 1979. Abnormalities of central contrast sensitivity in glaucoma. Am. J. Ophthalmol. 205–11.

  11. Trick, G.L. 1985. Retinal potentials in patients with primary open-angle glaucoma: Physiological evidence for temporal frequency tuning deficits. Invest. Ophthalmol. Vis. Sci. 26: 1750–8.

    Google Scholar 

  12. Tyler, C.W. 1981. Specific deficits in flicker sensitivity in glaucoma and ocular hypertension. Invest. Ophthalmol. Vis. Sci. 20: 204–12.

    Google Scholar 

  13. Arden, G.B., Carter, R.M., Hogg, C., Siegel, I.M., Morgolis, S. 1979. A gold foil electrode: extending the horizons for clinical electroretinography. Invest. Ophthalmol. Vis. Sci. 18: 421–6.

    Google Scholar 

  14. Berninger, T.A. 1986. The pattern electroretinogram and its contamination. Clin. Vision Sci. 1: 185–90.

    Google Scholar 

  15. Aulhorn, E., Karmeyer, H. Frequency distribution in early glaucomatous visual field defects. Doc. Ophthalmol. Proc. Series 14: 75–83.

  16. Kaplan, E., Shapley, R.M. 1986. The primate retina contains two types of ganglion cells, with high and low contrast sensitivity. Proc. Natl. Acad. Sci. USA 83: 2755–7.

    Google Scholar 

  17. Derrington, A.M., Lennie, P. 1984. Spatial and temporal contrast sensitivities of neurones in the lateral geniculate nucleus of macaque. J. Physiol. Lond. 357: 219–40.

    Google Scholar 

  18. Merigan, W.H., Eskin, T.A. 1986. Spatio-temporal vision of macaques with severe loss of P-β retinal ganglion cells. Vision Res. 26: 1751–61.

    Google Scholar 

  19. Trick, L.R. 1987. Age-related alterations in retinal function. Doc. Ophthalmol. 65: 35–44.

    Google Scholar 

  20. Porciatti, V., Falsini, B., Scalia, G., Fadda, A., Fontanesi, G. 1988. The pattern electroretinogram by skin electrodes: Effect of spatial frequency and age. Doc. Ophthalmol. 70: 117–22.

    Google Scholar 

  21. Wanger, P., Persson, H.E. 1987. Pattern-reversal electroretinograms from normotensive, hypertensive and glaucomatous eyes. Ophthalmologica 195: 205–8.

    Google Scholar 

  22. Shields, M.B. 1987. Textbook of Glaucoma. 2nd edition. Baltimore, London, Sydney: Williams & Wilkins.

    Google Scholar 

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Authors and Affiliations

  1. Universitäts-Augenklinik, Freiburg, FRG

    M. Bach & A. Speidel-Fiaux

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  1. M. Bach
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  2. A. Speidel-Fiaux
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Bach, M., Speidel-Fiaux, A. Pattern electroretinogram in glaucoma and ocular hypertension. Doc Ophthalmol 73, 173–181 (1989). https://doi.org/10.1007/BF00155035

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  • DOI: https://doi.org/10.1007/BF00155035

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