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The influence of age on the electroretinogram and visual evoked potential

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Abstract

Changes in the ERG and VEP across the life span were investigated. The dark adapted and scotopic ERGs both showed a progressive increase in the implicit times of the A and B waves and a reduction in the amplitude of the AB configuration. There was also an increase in the implicit times of the oscillatory potentials of the photopic ERG.

The flash and pattern onset-offset VEP both showed changes in waveform with age whilst the waveform of the pattern reversal VEP was constant. The amplitudes of the components of the flash and pattern reversal VEP were very high in the teenage group, but once reduced, were constant from the twenties onwards, showing no further consistent age changes.

The latencies of the components of the pattern VEPs showed an increase with age which could be accounted for by the reduction in retinal illuminance due to the decrease in pupil diameter with age. However, the increase in the latency of the flash major positive (P2) component was greater than that expected from the decrease in retinal illuminance alone, suggesting that this is due to neural factors.

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References

  • Allison T, Goff WR and Wood CC (1979) Auditory, somatosensory and visual evoked potentials in the diagnosis of neuropathology: Recording considerations and normative data. In: Lehmann D, Callaway E, eds. Human evoked potentials - applications and problems. New York, Plenum Press p 1–16

    Google Scholar 

  • Allison T, Wood CC and Goff WR (1983) Brainstem auditory, pattern reversal visual, and short latency somatosensory evoked potentials: latencies in relation to age, sex and brain and body size. Electroenceph Clin Neurophysiol 55:619–636

    Google Scholar 

  • Arden GB, Carter RM, Hogg C, Siegel IM and Margolis S (1979) A gold foil electrode: extending the horizons for clinical electroretinography. Invest Ophthal 18:421–426

    Google Scholar 

  • Asselman P, Chadwick DW and Marsden CD (1975) Visual evoked responses in the diagnosis and management of patients suspected of multiple sclerosis. Brain 98: 261–282

    Google Scholar 

  • Buchsbaum MS, Henkin RI and Christiansen RL (1974) Age and sex differences in averaged evoked responses in a normal population with observations on patients with gonadal dysgenesis. Electroenceph Clin Neurophysiol 37:137–144

    Google Scholar 

  • Celesia GG and Daly RF (1979) Effects of aging on visual evoked responses. Arch Neurol 34:403–407

    Google Scholar 

  • Copenhaver RM and Perry NW (1964) Factors affecting visually evoked cortical potentials such as impaired vision of varying etiology. Invest Ophthal 3:665–673

    Google Scholar 

  • Cosi V, Vitelli E, Gozzoli L, Corona A, Ceroni M and Callieco R (1982) Visual evoked potentials in aging of the brain. In: Courjon J, Mauguiere F, Revol M, eds. Clinical applications of evoked potentials in neurology. New York, Raven Press, pp 109–115

    Google Scholar 

  • Creutzfeldt OD and Kuhnt U (1967) The visual evoked potential: physiological, developmental and clinical aspects. Electroenceph Clin Neurophysiol: 26 (Suppl):29–41

    Google Scholar 

  • Drasdo N (1976) A method of eliciting pattern specific responses and other electrophysiological signals in human subjects. Brit J Physiol Opt 31:14–22

    Google Scholar 

  • Dustman RE and Beck EC (1966) Visually evoked potentials: amplitude changes with age. Science 151:1013–1015

    Google Scholar 

  • Dustman RE and Beck EC (1969) The effects of maturation and aging on the waveform of visually evoked potentials. Electroenceph Clin Neurophysiol 26:2–11

    Google Scholar 

  • Dustman RE, Schenkenberg T, Lewis EG and Beck EC (1977) The cerebral evoked potential: Life span changes and twin studies in man: Desmedt JE, ed. Visual evoked potentials in man. Oxford, Clarendon Press, pp 363–377

    Google Scholar 

  • Halliday AM (1980) Event related potentials and their diagnostic usefulness. In: Kornhuber HH, Deecke L, eds. Motivation, motor and sensory processes of the brain. Progress in Brain Research, Vol 54. Amsterdam, Elsevier/North Holland Biomedical Press, pp 470–485

    Google Scholar 

  • Halliday AM, Barrett G, Carroll W and Kriss A (1982) Problems in defining the normal limits of the visual evoked potential. In: Courjon J, Mauguiere F, Revol M, eds. Clinical applications of evoked potentials in neurology. New York, Raven Press, pp 1–10

    Google Scholar 

  • Halliday AM, McDonald WI and Mushin J (1973) Delayed pattern evoked responses in optic neuritis in relation to visual acuity. Trans Ophthal Soc UK 93:315–324

    Google Scholar 

  • Harding GFA, Doggett CE, Orwin A and Smith EJ (1981) Visual evoked potentials in pre-senile dementia. In: Spekreijse H and Apkarian PA, eds Docum Ophthal Proc Ser 27:193–202

  • Harding GFA, Williams DE and Innes JA (1984) The visual evoked response and visual psychophysics during Ethambutol therapy In: Proc. 2nd Evoked Potentials Symposium, London, Butterworth (In Press).

    Google Scholar 

  • Jeffreys DA (1977) The physiological significance of pattern visual evoked potentials. In: Desmedt JE, ed. Visual evoked potentials in man: new developments. Oxford, Clarendon Press, pp. 134–167

    Google Scholar 

  • Karpe G, Rickenbach K and Thomasson S (1950) The clinical electroretinogram. 1. The normal electroretinogram above fifty years of age. Acta Ophthal 28:301–305

    Google Scholar 

  • Keppel G (1973) Design and analysis: A researchers handbook. Englewood Clifts N.J., Prentice Hall

    Google Scholar 

  • Kinney JAS (1977) Transient visually evoked potential. J Opt Soc Amer 67:1465–1474

    Google Scholar 

  • Kooi KAand Bagchi BK (1964) Visual evoked responses in man: normative data. Ann N Y Acad Sci 112:254–269

    Google Scholar 

  • Martin DA and Heckenlively JR (1982) The normal electroretinogram Docum Ophthal Proc Ser 31:135–144

    Google Scholar 

  • Peterson H (1968) The normal B-potential in the single flash clinical electroretinogram. Acta Ophthal Suppl 99:5

    Google Scholar 

  • Shaw NA and Cant B (1981) Age dependent changes in the amplitude of the pattern visual evoked potential. Electroenceph Clin Neurophysiol 51:671–673

    Google Scholar 

  • Snyder EW, Dustman RE and Shearer PE (1981) Pattern reversal evoked potential amplitude: Life span changes. Electroenceph Clin Neurophysiol 52:429–434

    Google Scholar 

  • Sokol S, Moskowitz Aand Towle VL (1981) Age related changes in the latency of the visual evoked potential: influence of check size. Electroenceph Clin Neurophysiol 51:559–562

    Google Scholar 

  • Spekreijse H, Van der Tweel LH and Zuidema TH (1973) Contrast evoked responses in man. Vision Res 13:1577–1601

    Google Scholar 

  • Stockard JJ, Hughes JF and Sharborough FW (1979) Visually evoked potentials to electronic pattern reversal: latency variations with gender age and technical factors. Amer J EEG Technol 19:171–204

    Google Scholar 

  • Straub W (1961) Einige Erkrankungen des Sehnerven in electroretinographischer Sicht. Vision Res 1:220–227

    Google Scholar 

  • Vainio-Mattilo B (1951) The clinical electroretinogram: The difference between the electroretinogram in men and women. Acta Ophthal 29:25–32

    Google Scholar 

  • Van der Tweel LH, Estevez O and Cavonius CR (1979) Invariance of the contrast evoked potential with changes in retinal illuminance. Vision Res 19:1283–1287

    Google Scholar 

  • Vries-Khoe LH de and Spekreijse H (1982) Maturation of luminance and pattern EPs in man. Docum Ophthal Proc Ser 31:461–475

    Google Scholar 

  • Weleber RG (1981) The effect of age on human cone and rod Ganzfeld electroretinograms. Invest Ophthal 20:392–399

    Google Scholar 

  • Williams DE (1983) The effect on visual electrophysiological investigations of substances primarily inducing a deleterious effect on the retinal ganglion cells and/or higher up in the visual pathway. Unpublished PhD thesis. The University of Aston in Birmingham, England.

    Google Scholar 

  • Wright CE and Drasdo N (1985) The influence of age on the spatial and temporal contrast sensitivity function. Docum Ophthal 59:385–395

    Google Scholar 

  • Wright CE, Drasdo, N and Harding GFA (1984a) Electrophysiological and psychophysical studies on suspected unilateral retrobulbar neuritis. Transactions of the 1st International congress of the British College of Ophthalmic Opticians, Vol 1, pp 69–93

    Google Scholar 

  • Wright CE, Harding GFA and Orwin A (1984b) Pre-senile dementia - the use of the flash and pattern VEP in diagnosis. Electroenceph Clin Neurophysiol 57:405–415

    Google Scholar 

  • Zeidler I (1959) The clinical electroretinogram. The normal ERG value of the B potential in different age groups and its differences in men and women. Acta Ophthal 37:294–301

    Google Scholar 

  • Zetterstrom B (1956) Studies on the postnatal development of the electroretinogram in newborn infants. Stockholm, Karolinska Sjukuset

    Google Scholar 

Download references

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Authors and Affiliations

  1. The Clinical Neurophysiology Unit, Department of Ophthalmic Optics, The University of Aston in Birmingham, Woodcock Street, B4 7ET, Gosta Green, Birmingham, Great Britain

    C. E. Wright, D. E. Williams, N. Drasdo & G. F. A. Harding

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  1. C. E. Wright
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  2. D. E. Williams
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  3. N. Drasdo
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  4. G. F. A. Harding
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Wright, C.E., Williams, D.E., Drasdo, N. et al. The influence of age on the electroretinogram and visual evoked potential. Doc Ophthalmol 59, 365–384 (1985). https://doi.org/10.1007/BF00159171

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