Abstract
High-dose thiotepa with autologous bone marrow rescue is a new and promising treatment modality in several kinds of solid tumors. We used this regimen in a pediatric patient who had the third recurrence of his malignant oligodendroglioma of brain that developed during ‘8 in 1’ chemotherapy. We achieved complete response after a total dose of 1125 mg/m2 of intravenous thiotepa. Good penetration into the CNS renders thiotepa potentially useful for chemosensitive brain tumors, and one course of high-dose thiotepa can be administered with acceptable toxicity by utilizing autologous bone marrow rescue.
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Saarinen, U.M., Pihko, H. & Mäkipernaa, A. High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma: A case report. J Neuro-Oncol 9, 57–61 (1990). https://doi.org/10.1007/BF00167069
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DOI: https://doi.org/10.1007/BF00167069