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The prognostic significance of postoperative residual contrast enhancement on CT scan in pediatric patients with medulloblastoma

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Abstract

The clinical and therapeutic features of 20 patients with medulloblastoma treated at Childrens' Hospital and Medical Center, Seattle, from 1980 to 1987, were retrospectively analyzed with regard to prognosis. The overall actuarial 5-year survival rate was 63%, with 57% of patients free from recurrence at 5 years. Residual contrast enhancement on CT scans taken immediately postoperatively was associated with a significantly decreased 5-year recurrence-free survival rate; the 5-year recurrence-free survival rate was 100% for those patients without post-operative residual enhancement compared to 41% for those patients with residual enhancement. A high risk group of patients with residual contrast enhancement persisting one year following diagnosis was identified. No patient in this group survived without disease progression. Other factors, including sex, age at diagnosis, evidence of tumor dissemination, or extent of surgical resection as reported by the neurosurgeon, did not significantly influence prognosis.

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Authors and Affiliations

  1. PediatricsChildren's Hospital & Med Center, University of Washington, Seattle, Washington, USA

    Jeffrey P. Bourne & Russell Geyer

  2. Neurological Surgery, Children's Hospital & Med Center, University of Washington, Seattle, Washington, USA

    Mitchel Berger

  3. Radiation Oncology, Children's Hospital & Med Center, University of Washington, Seattle, Washington, USA

    Brian Griffin

  4. Neurology, Children's Hospital & Med Center, University of Washington, Seattle, Washington, USA

    Jerrold Milstein

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  1. Jeffrey P. Bourne
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  2. Russell Geyer
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  3. Mitchel Berger
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  4. Brian Griffin
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  5. Jerrold Milstein
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Bourne, J.P., Geyer, R., Berger, M. et al. The prognostic significance of postoperative residual contrast enhancement on CT scan in pediatric patients with medulloblastoma. J Neuro-Oncol 14, 263–270 (1992). https://doi.org/10.1007/BF00172602

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  • DOI: https://doi.org/10.1007/BF00172602

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