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Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies

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Abstract

A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.

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Authors and Affiliations

  1. Max-Planck-Society, Clinical Research Unit for Rheumatology/Immunology, Schwabachanlage 10, D-91054, Erlangen, Germany

    R. W. Kinne & F. Emmrich

  2. Department of Nuclear Medicine, University of Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054, Erlangen, Germany

    W. Becker & F. Wolf

  3. Institute of Clinical Immunology and Rheumatology, Department of Medicine III, University of Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054, Erlangen, Germany

    J. Schwab, J. R. Kalden & G. R. Burmester

  4. Radiochemical Laboratory of the Behring Werke (Hoechst AG), Stroofstrasse, D-65933, Frankfurt, Germany

    A. Schwarz

Authors
  1. R. W. Kinne
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  2. W. Becker
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  3. J. Schwab
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  4. A. Schwarz
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  5. J. R. Kalden
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  6. F. Emmrich
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  7. G. R. Burmester
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  8. F. Wolf
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Correspondence to: R.W. Kinne

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Kinne, R.W., Becker, W., Schwab, J. et al. Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies. Eur J Nucl Med 21, 176–180 (1994). https://doi.org/10.1007/BF00175768

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  • DOI: https://doi.org/10.1007/BF00175768

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