Skip to main content
Log in

Evolving principles in immunopathology: interleukin 10 and its relationship to Epstein-Barr virus protein BCRF1

  • Concepts in Viral Biology
  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, Tuffnell PS, Barrell BG (1984) DNA sequence and expression of the B95–8 Epstein-Barr virus genome. Nature 310: 207.

    Google Scholar 

  2. Banchereau J, de Paoli P, Valle A, Garcia E, Rousset F (1991) Long term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 251: 70.

    Google Scholar 

  3. Beck S, Barrell BG (1988) Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature 331: 269.

    Google Scholar 

  4. Boom WH, Liano D, Abbas AK (1988) Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes. J Exp Med 167: 1352.

    Google Scholar 

  5. Chen WF, Zlotnik A (1991) IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 147: 528.

    Google Scholar 

  6. Cher DJ, Mosmann TR (1987) Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. J Immunol 138: 3688.

    Google Scholar 

  7. Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR (1987) Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 166: 1229.

    Google Scholar 

  8. de Waal Malefyt R, Haanen J, Spits H, Roncarolo M-G, te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, de Vries JE (1991) IL 10 and viral IL 10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II MHC expression. J Exp Med (in press).

  9. Fernandez-Botran R, Sanders VM, Mosmann TR, Vitetta ES (1988) Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. J Exp Med 168: 543.

    Google Scholar 

  10. Fiorentino DF, Bond MW, Mosmann TR (1989) Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170: 2081.

    Google Scholar 

  11. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Morre KW, O'Garra A (1991) IL 10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146: 3444.

    Google Scholar 

  12. Gajewski TF, Fitch FW (1988) Anti-proliferative effect on IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 140: 4245.

    Google Scholar 

  13. Gaynor ER, Vitek L, Sticklin L, Creekmore SP, Ferraro ME, Thomas JX, Fisher SG, Fisher RI (1988) The hemodynamic effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med 109: 953.

    Google Scholar 

  14. Go NF, Castle BE, Barrett R, Kastelein R, Dang W, Mosmann TR, Moore KW, Howard M (1990) Interleukin 10 (IL 10), a novel B cell stimulatory factor: unresponsiveness of xchromosome-linked immunodeficiency B cells. J Exp Med 172: 1625.

    Google Scholar 

  15. Gosselin J, Menezes J, Mercier G, Lamoureux G, Oth D (1989) Differential interleukin-2 and interferon-gamma production by human lymphocyte cultures exceptionally resistant to Epstein-Barr virus immortalization. Cell Immunol 122: 440.

    Google Scholar 

  16. Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB (1983) Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation. J Exp Med 157: 173.

    Google Scholar 

  17. Herberman R, (1990) Therapy of cancer with interleukin-2-activated natural killer cells. Ther Adv Melanoma 10: 141.

    Google Scholar 

  18. Hsu D-H, de Waal Malefyt R, Fiorentino DF, Dang M-N, Vieira P, de Vries J, Spits H, Mosmann TR, Moore KW (1990) Expression of IL 10 activity by Epstein-Barr Virus Protein BCRFI. Science 250: 830.

    Google Scholar 

  19. Reference deleted.

  20. Hudson GS, Bankier AT, Satchwell SC, Barrell BG (1985) The short unique region of the B95–8 Epstein-Barr virus genome. Virology 147: 81.

    Google Scholar 

  21. Kasid A, Director EP, Rosenberg SA (1989) Induction of endogenous cytokne mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients. J Immunol 143: 736.

    Google Scholar 

  22. Katsura Y (1977) Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivity and antibody response. Immunology 32: 227.

    Google Scholar 

  23. Killar L, MacDonald G, West J, Woods A, Bottomly K (1987) Cloned, Ia-restricted T cells that do not produce interleukin 4 (IL-4)/B cell stimulatroy factor I (BSF-1) fail to help antigen-specific B cells. J Immunol 138: 1674.

    Google Scholar 

  24. Kotwal GJ, Isaacs SN, McKenzie R, Frank MM, Moss B (1990) Inhibition of the complement cascade by the major secretory protein of vaccinia virus. Science 250: 827.

    Google Scholar 

  25. Lee RE, Lotze MT, Skibber JM, Tucker E, Bonow RO, Ognibene FP, Carrasquillo JA, Shelhammer JH, Parrillo JE, Rosenberg SA (1989) Cardiorespiratory effects of immunotherapy with interleukin-2. J Clin Oncol 7: 7.

    Google Scholar 

  26. Lotz M, Tsoukas CD, Fong S, Carson DA, Vaughan JH (1985) Regulation of Epstein-Barr virus infection by recombinant interferons. Selected sensitivity to interferon-gamma. Eur J Immunol 15: 520.

    Google Scholar 

  27. MacNeil I, Suda T, Moore KW, Mosmann TR, Zlotnik A (1990) I1–10: a novel cytokine growth cofactor for mature and immature T cells. J Immunol 145: 4167.

    Google Scholar 

  28. Masucci MG, Bejarano MT, Masucci G, Klein E (1983) Large granular lymphocytes inhibit the in vitro growth of autologous Epstein-Barr virus-infected B cells. Cell Immunol 76: 311.

    Google Scholar 

  29. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR (1990) Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein Barr Virus gene BCRFI. Science 248: 1230.

    CAS  PubMed  Google Scholar 

  30. Mosmann TR, Moore KW (1991) The role of IL-10 in cross-regulation of Th1 and Th2 responses. Immunol Today 12: A49.

    Google Scholar 

  31. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348.

    Google Scholar 

  32. Mosmann TR, Schumacher J, Fiorentino DF, Leverah J, Moore KW, Bond MW (1990) Isolation of monoclonal antibodies specific for IL 4, IL 5, IL 6 and a new Th2-specific cytokine (IL 10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J Immunol 145: 2938.

    Google Scholar 

  33. O'Garra A, Stapleton G, Dhar V, Pearce M, Schumacher J, Rugo H, Barbis D, Stall A, Cupp J, Moore K, Vieira P, Mosmann T, Whitmore A, Arnold L, Haughton G, Howard M (1990) Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10. Int Immunol 2: 821.

    Google Scholar 

  34. Parish CR (1972) The relationship between humoral and cell-mediated immunity. Transplant Rev 13: 35.

    Google Scholar 

  35. Purtilo DT (1985) Epstein-Barr virus-induced diseases in the X-linked lymphoproliferative syndrome and related disorders. Biomed Pharmacother 39: 562.

    Google Scholar 

  36. Rosenstein M, Ettinghausen SE, Rosenberg SA (1986) Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2. J Immunol 137: 1735.

    Google Scholar 

  37. Reference deleted.

  38. Rousset F, Garcia E, Banchereau J (1991) Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J Exp Med 173: 705.

    Google Scholar 

  39. Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Goodwin RG (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248: 1019.

    Google Scholar 

  40. Stout RD, Bottomly KD (1989) Antigen-specific activation of effector macrophages by IFNγ-producing (Th1) T cell clones. Failure of IL 4-producing (Th2) T cell clones to activate effector fuction in macrophages. J Immunol 142: 760.

    Google Scholar 

  41. Suda T, O'Garra A, MacNeil I, Fischer M, Bond M, Zlotnik A (1990) Identification of a novel thymocyte growth-promoting factor derived from B call lymphomas. Cell Immunol 129: 228.

    Google Scholar 

  42. Thompson-Snipes L, Dhar V, Bond MW, Mosmann TR, Moore KW, Rennick D (1991) Interleukin-10: a novel stimulatory factor for mast cells and their progenitors. J Exp Med 173: 507.

    Google Scholar 

  43. Thorley-Lawson DA (1980) The suppression of Epstein-Barr virus infection in vitro occurs after infection but before transformation of the cell. J Immunol 124: 745.

    Google Scholar 

  44. Thorley-Lawson DA (1981) The transformation of adult but not newborn human lymphocytes by Epstein-Barr virus and phytohemagglutinin is inhibited by interferon: the early suppression by T cells of Epstein-Barr virus infection is mediated by interferon. J Immunol 126: 829.

    Google Scholar 

  45. Thorley-Lawson DA (1988) Immunological responses to Epstein-Barr virus infection and the pathogenesis of EBV-induced diseases. Biochim Biophys Acta 948: 263.

    Google Scholar 

  46. Tosato G (1987) The Epstein-Barr virus and the immune system. Adv Cancer Res 49: 75.

    Google Scholar 

  47. Trinchieri G, Matsumoto-Kobayashi M, Clark SC, Seehra J, London L, Perussia B (1984) Response of resting human peripheral blood natural killer cells to interleukin 2. J Exp Med 160: 1147.

    Google Scholar 

  48. Vieira P, de Waal-Malefyt R, Dang M-N, Johnson KE, Kastelein R, Fiorentino DF, deVries JE, Roncarolo M-G, Mosmann TR, Moore KW (1991) Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL10) cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci USA 88: 1172.

    Google Scholar 

  49. Young HA, Ortaldo JR (1987) One-signal requirement for interferon-gamma production by human large granular lymphocytes. J Immunol 139: 724.

    Google Scholar 

  50. Zlotnik A, Moore KW (1991) Interleukin 10. Cytokine (in press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moore, K.W., Rousset, F. & Banchereau, J. Evolving principles in immunopathology: interleukin 10 and its relationship to Epstein-Barr virus protein BCRF1. Springer Semin Immunopathol 13, 157–166 (1991). https://doi.org/10.1007/BF00201466

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00201466

Keywords

Navigation