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Facilitation of latent inhibition by haloperidol in rats

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Abstract

Latent inhibition (LI) is a behavioral paradigm in which prior exposure to a stimulus not followed by reinforcement retards subsequent conditioning to that stimulus when it is paired with reinforcement. Two experiments investigated the effects of 0.1 mg/kg haloperidol administration on LI as a function of number of CS pre-exposures. The investigation was carried out using a conditioned emotional response (CER) procedure consisting of three stages: pre-exposure, in which the to-be-conditioned stimulus, tone, was repeatedly presented without reinforcement; conditioning, in which the pre-exposed stimulus was paired with shock; and test, where LI was indexed by animals' suppression of licking during tone presentation. The three stages were conducted 24 h apart. In Experiment 1, 40 CS pre-exposures were given. LI was obtained in both the placebo and haloperidol conditions, but the effect was much more pronounced under the drug. Experiment 2 used ten CS pre-exposures. LI was not obtained in the placebo animals but was clearly evident in animals injected with haloperidol. The implications of these findings for the effects of neuroleptics on learning are discussed.

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  1. Department of Psychology, Tel-Aviv University, Ramat-Aviv, Israel

    I. Weiner & J. Feldon

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  1. I. Weiner
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  2. J. Feldon
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Weiner, I., Feldon, J. Facilitation of latent inhibition by haloperidol in rats. Psychopharmacology 91, 248–253 (1987). https://doi.org/10.1007/BF00217073

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  • DOI: https://doi.org/10.1007/BF00217073

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