Abstract
Results from previous studies on monkeys and human subjects have demonstrated that the biceps brachii spinal stretch reflex (SSR) can be operantly conditioned. The extent to which conditioning paradigms influence contralateral SSRs or longer latency responses in the same limb has not been examined. Nine subjects were given 10 training sessions to either increase or decrease the size of their biceps brachii SSR. Group changes were compared to the mean of six baseline (control) sessions. Both groups showed progressive SSR changes over the training sessions. Up-trained subjects increased their SSR responses by an average of 135.3% above baseline, with the last three sessions showing a 237.5% increase, while down-trained subjects reduced their average SSR responses by 43.4%, with a 52.7% reduction over the last three sessions. Ipsilateral longer latency responses showed average changes of 68.9% and-68.7% for up- and down-trainers, respectively. As in the case of SSRs, these responses changed progressively over sessions, with a 131.5% increase seen in the last three up-training sessions and an 82.4% reduction over the same period for down-trainers. Correlation coefficients between SSR and longer latency responses were high (R=0.90, up-trainers; R=0.87, down-trainers). Contralateral SSR and longer latency responses, measured in the absence of feedback and at least 10 min after ipsilateral conditioning, showed directional changes that were similar to the trained side, but their magnitudes were not as profound. Collectively, these data suggest that unilateral SSR conditioning affects spinal circuits controlling contralateral SSRs and influences longer latency responses.
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References
Carp JS, Wolpaw JR (1991) Possible mechanisms of operantly conditioned plasticity in motoneuron response to Ia afferent input. In: Wernig A (ed) Plasticity of motoneuronal connections. (Restorative neurology, vol 5). Eisevier, Amsterdam, pp 435–442
Carp JS, Chen XY, Wolpaw JR (1993) Alteration in firing threshold and axonal conduction velocity of primate spinal motoneurons by H-reflex operant conditioning: experimental studies. Soc Neurosci Abstr 19:537
Catlin PA, Wolf SL, Gabrielson L, Kassel T, Martin S (1993) Contralateral effects of conditioning the biceps brachii spinal stretch reflex. Soc Neurosci Abstr 19:1595
Chan CW, Kearney CE (1983) Is the functional stretch response servo-controlled or preprogrammed? Electrocephalogr Clin Neurophysiol 53:310–324
Crago PE, Houk JC, Kasan Z (1976) Regulatory action of human stretch reflex. J Neurophysiol 39:925–935
Evatt ML, Wolf SL, Segal RL (1989) Modification of human spinal stretch reflexes: preliminary studies. Neurosci Lett 105:350–355
Ghez C, Shinoda Y (1978) Spinal mechanisms of the functional stretch reflex. Exp Brain Res 32:55–68
Goodin DS, Aminoff MJ (1992) The basis and functional role of the late EMG activity in human forearm muscles following wirst displacement. Brain Res 589:39–47
Hallett M, Bielawski M, Marsden CD (1981) Behavior of the long-latency stretch reflex prior to voluntary movement. Brain Res 219:178–185
Kirsch RF, Kearney RE, MacNeil JB (1993) Identification of timevarying dynamics of the human triceps surae stretch reflex. Exp Brain Res 97:115–127
Kupfermann I (1981) Learning. In: Kandel ER, Schwartz JH (eds) Principles of neural science, 1st edn. Elsevier/North Holland, Amsterdam, pp 572–573
Marsden CD, Merton PA, Morton HB (1972) Servo-action in human voluntary movement. Nature 238:140–143
Matthews PBC (1991) The human stretch reflex and the motor cortex. Trends Neurosci 14:87–91
Melvill Jones G, Watt GD (1971) Observations on the control of stepping and hopping movements in man. J Physiol (Lond) 219:709–727
Rothwell JC, Day BL, Berardelli A, Marsden CD (1986) Habituation and conditioning of the human long latency stretch reflex. Exp Brain Res 63:197–204
Segal RL, Wolf SL (1993) Variability of human biceps brachii spinal stretch reflexes: control conditions. J Electromyogr Kinesiol 3:24–32
Segal RL, Wolf SL (1994) Operant conditioning of spinal stretch reflexes in patients with spinal cord injury. Exp Neurol 130:202–213
Segal RL, Catlin PA, Cook R, Johnson L, McCullum A, Murzin D, Rubel K, Wolf SL (1989) Preliminary studies on modifications of hyperactive spinal stretch reflexes in stroke patients. Soc Neurosci Abstr 15:917
Starr KA, Wolpaw JR (1994) Synaptic terminal coverage of primate triceps surae motoneurons. J Comp Neurol 345:345–358
Thilmann AF, Schwarz M, Topper R, Fellows SJ, Noth J (1991) Different mechanisms underlie the long-latency stretch reflex response of active human muscle at different joints. J Physiol (Lond) 444:631–643
Vilis T, Cooke JD (1976) Modulation of the functional stretch reflex by the segmental reflex pathway. Exp Brain Res 25:247–254
Waterston (1991) Falls in the elderly — future strategies. J R Soc Med 84:189–191
Wolf SL, Segal RL (1990) Conditioning of the spinal stretch reflex: implications for rehabilitation. Phys Ther 70:652–656
Wolf SL, LeCraw DE, Barton LA (1989) Comparison of motor copy and targeted biofeedback training techniques for restoration of upper extremity function among patients with neurologic disorders. Phys Ther 69:719–735
Wolf SL, Segal RL, Nichols TR, Vitek JL, Watts R (1993) Functional changes with stretch reflex conditioning. Soc Neurosci Abstr 19:1594
Wolpaw JR, Carp JS (1993) Adaptive plasticity in spinal cord. In: Seil FJ (ed) Advances in neurology, vol 59. Raven Press, New York, pp 163–174
Wolpaw JR, O'Keefe JA (1984) Adaptive plasticity in the primate spinal stretch reflex: evidence for a two-phase process. J Neurosci 4:2718–2724
Wolpaw JR, Seegal RF, O'Keefe JA (1983) Adaptive plasticity in the primate spinal stretch reflex: behavior of Synergist and antagonist muscles. J Neurophysiol 59:1312–1319
Wolpaw JE, O'Keefe JA, Kieffer VA, Sanders MG (1985) Reduced day-to-day variation accompanies adaptive plasticity in the primate spinal stretch reflex. Neurosci Lett 54:165–171
Wolpaw JR, O'Keefe JA, Noonan PA, Sanders MG (1986) Adaptive plasticity in the primate stretch reflex: persistence. J Neurophysiol 55:272–279
Wolpaw JR, Lee CL, Calaitges GJ (1989) Operant conditioning of primate triceps surea-reflex produces reflex asymmetry. Exp Brain Res 75:35–39
Wolpaw JR, Herchenroder PA, Carp JS (1993) Operant conditioning of triceps surae H-reflex: factors affecting the magnitude of change. Exp Brain Res 97:31–39
Wolpaw JR, Maniccia DM, Elia T (1994) Operant conditioning of primate H-reflex: phases of development. Neurosci Lett 170:203–207
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Wolf, S.L., Segal, R.L., Heter, N.D. et al. Contralateral and long latency effects of human biceps brachii stretch reflex conditioning. Exp Brain Res 107, 96–102 (1995). https://doi.org/10.1007/BF00228021
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DOI: https://doi.org/10.1007/BF00228021