Abstract
Monkeys with medial premotor cortex (MPC) lesions are impaired on a simple learned task that requires them to raise their arm at their own pace. However, they can succeed on this task if they are given tones to guide performance. In the externally paced task the tones could aid performance in several ways. They tell the animal when to act (trigger), they remind the animal that food is available and so motivate (predictor), and they remind the animal of what to do (instruction). Monkeys with MPC lesions can respond quickly to visual cues (experiment 1), and they can respond as well as normal monkeys when there is no immediate trigger (experiment 2). They are also quick to relearn a task in which external cues tell them what to do (experiment 5). However, they are poor at selecting between movements on a simple motor sequence task (experiment 3), and they are poor at changing between two movements (experiment 4). On these tasks there were cues to act as triggers and predictors, but there were no external instructions. We conclude that the reason why animals with MPC lesions perform better with external cues is that these cues act as instructions. The cues prompt retrieval of the appropriate action. This is true whether the task requires the animal to perform one action (experiments 1 and 2) or to select between actions (experiments 3 and 4).
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References
Canavan AGM, Nixon PD, Passingham RE (1989) Motor learning in monkeys (Macaca fascicularis) with lesions in motor thalamus. Exp Brain Res 77:113–126
Deiber M-P, Passingham RE, Colebatch JG, Friston KJ, Nixon PD, Frackowiak RSJ (1991) Cortical areas and the selection of movement: a study with positron emission tomography. Exp Brain Res 84:393–402
Eccles JC (1982) The initiation of voluntary movements by the supplementary motor cortex. Arch Psychiatr Nervenkr 231:423–441
Goldberg G (1985) Supplementary motor area structure and function: review and hypotheses. Behav Brain Res 8:567–588
Halsband U (1982) Higher Movement Disorders in Monkeys, Unpublished D. Phil. thesis, Oxford University
Halsband U (1987) Higher disturbances of movement in monkeys (Macaca mulatta). In: Gantchev GN, Dimitev B, Gatev PC (ed) Motor control. Plenum, New York, pp 79–85
Halsband U, Passingham RE (1985) Premotor cortex and the conditions for movement in monkeys (Macaca fascicularis). Behav Brain Res 18:267–277
Jenkins IH, Passingham RE, Nixon PD, Frackowiak RSJ, Brooks DJ (1992) The learning of motor sequences: a PET study. Eur J Neurosci
Jenkins IH, Brooks DJ, Nixon PD, Frackowiak RSJ, Passingham RE (1994) Motor sequence learning: a study with positron emission tomography. J Neurosci (in press)
Mushiake H, Inase M, Tanji J (1990) Selective coding of motor sequence in the supplementary motor area of the monkey cerebral cortex. Exp Brain Res 82:208–210
Mushiake H, Inase M, Tanji J (1991) Neuronal activity in the primate premotor, supplementary, and precentral motor cortex during visually guided and internally determined sequential movements. J Neurophysiol 66:705–718
Niki H, Watanabe M (1979) Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res 171:213–224
Okano K, Tanji J (1987) Neuronal activity in the primate motor fields of the agranular frontal cortex preceding visually triggered and self-paced movements. Exp Brain Res 66:155–166
Passingham RE (1987) Two cortical systems for directing movements. In: Porter R (ed) Motor areas of the cerebral cortex. (CIBA symposium, 132) Wiley, Chichester, pp 151–164
Passingham RE (1993) The frontal cortex and voluntary action. (Oxford psychology series, no 21) Oxford University Press, Oxford
Roland PE, Meyer E, Shibasaki T, Yamamoto YL (1982) Regional blood flow changes in cortex and basal ganglia during voluntary movements in normal human volunteers. J Neurophysiol 48:467–480
Roland PE, Gulyas B, Seitz RJ (1991) Structures in the human brain participating in visual learning, tactile learning, and motor learning. In: Squire LR, Weinberger NM, Lynch G, McGaugh JL (ed) Memory: organization and locus of change. Oxford University Press, New York, pp 95–113
Seitz RJ, Roland PE, Bohm C, Greitz T, Stone-Elanders S (1990) Motor learning in man: a positron emission tomographic study. Neuroreport 1:17–20
Shima K, Aya K, Mushiake H, Inase M, Aizawa H, Tanji J (1991) Two movement-related foci in the primate cingulate cortex observed in signal-triggered and self-paced forelimb movements. J Neurophysiol 65:188–202
Tanji J, Kurata K, Okano K (1985) The effect of cooling of the supplementary motor cortex and adjacent cortical areas. Exp Brain Res 60, 423–426
Thaler D, Chen Y-C, Nixon PD, Stern C, Passingham RE (1994) The functions of the medial premotor cortex. I. Simple learned movements. Exp Brain Res 102:445–460
Zeffiro TA, Kertzmann C, Peilzzari C, Hallet M (1991) The role of the supplementary motor area in the control of self-paced movements: a PET study. Soc Neurosci Abstr 17:443.3
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Chen, Y.C., Thaler, D., Nixon, P.D. et al. The functions of the medial premotor cortex. Exp Brain Res 102, 461–473 (1995). https://doi.org/10.1007/BF00230650
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DOI: https://doi.org/10.1007/BF00230650