Summary
The generators of brainstem auditory evoked potentials (BAEPs) in rats were investigated experimentally. Discrete lesions of the brainstem auditory pathway were made unilaterally using a stereotaxic radiofrequency coagulation method, and the BAEPs were recorded before and after the lesions to observe the alterations. The waves of the BAEPs were affected by the lesions as follows: (1) all of the BAEP waves were attenuated or eliminated by a lesion of the auditory nerve; (2) wave II was abolished or attenuated in amplitude following a lesion of the cochlear nucleus; (3) marked reduction or abolition of wave III occurred with some effect on waves IV and V following lesions of the superior olivary complex; (4) the following trough in the wave III was significantly attenuated by lesions of the lateral lemniscus that were associated with inconsistent changes in waves IV and V; (5) no waves were affected significantly by a lesion of the inferior colliculus. The method of radiofrequency lesion using stereotaxic localization proved to be a simpler and more rapid procedure for determining the generators of BAEPs in animals than other surgical lesion methods.
Similar content being viewed by others
References
Achor LJ, Starr A (1980a) Auditory brain stem responses in the cat. I. Intracranial and extracranial recordings. Electroencephalogr Clin Neurophysiol 48:154–157
Achor LJ, Starr A (1980b) Auditory brain stem responses in the cat. II. Effects of lesions. Electroencephalogr Clin Neurophysiol 48:174–190
Buchwald JS, Huang CM (1975) Far-field acoustic response: origins in the cat. Science 189:382–384
Caird DM, Klinke R (1987) The effect of inferior colliculus lesions on auditory evoked potentials. Electroencephalogr Clin Neurophysiol 68:237–240
Caird D, Sontheimer D, Klinke R (1985) Intra- and extracranially recorded auditory evoked potentials in the cat. I. Source location and binaural interaction. Electroencephalogr Clin Neurophysiol 61:50–60
Chen TJ, Chen SS (1990) Brain stem auditory-evoked potentials in different strains of rodents. Acta Physiol Scand 138:529–538
Chen TJ, Hsu HK, Chen SS (1988) Brain stem auditory evoked potentials in brain stem dysfunction. Kaohsiung J Med Sci 4:238–247
Ciganek L, Smieskova A, Hruby M, Mladonicky P (1984) Processing and analysis techniques for brain-stem auditory evoked potentials with localization of brain-stem lesions. Electroencephalogr Clin Neurophysiol 57:92–96
Funai H, Funasaka S (1983) Experimental study on the effect of inferior colliculus lesions upon auditory brain stem response. Audiology 22:9–19
Galambos R, Despland PA (1980) The auditory brainstem response (ABR) evaluates risk factors for hearing loss in the newborn. Pediat Res 14:159–163
Gardi JN, Bledsoe SC (1981) The use of kainic acid for studying the origins of scalp-recorded auditory brainstem responses in the guinea pig. Neurosci Lett 26:143–149
Greenberg RP, Stablein DM, Becker DP (1981) Noninvasive localization of brain-stem lesions in the cat with multimodality evoked potentials: correlation with human head-injury data. J Neurosurg 54:740–750
Hsu CC, Chen TJ, Jin SH, Chen SS (1989) Electrophysiological studies of acute anoxic hypoxia. Kaohsiung J Med Sci 5:670–675
Jewett DL (1970) Averaged volume-conducted potentials to auditory stimuli in the cat. Electroencephalogr Clin Neurophysiol 28:609–618
Jewett DL, Romano MN (1972) Neonatal development of auditory system potentials averaged from the scalp of rat and cat. Brain Res 36:101–115
Kjaer M (1980) Localizing brain stem lesions with brain stem auditory evoked potentials. Acta Neurol Scand 61:265–274
Legatt AD, Arezzo JC, Vaughan HG (1986) Short-latency auditory evoked potentials in the monkey. II. Intracranial generators. Electroencephalogr Clin Neurophysiol 64:53–73
Lumenta CB, Schober R, Sprick C, Bock WJ (1986) Findings confirming brainstem generators of auditory evoked potentials by stereotatic lesions in the rabbit. Neurol Res 8:114–116
Moller AR, Burgess J (1986) Neural generators of the brain-stem auditory evoked potentials (BAEPs) in the rhesus monkey. Electroencephalogr Clin Neurophysiol 65:361–372
Moller AR, Jannetta P (1982) Evoked potentials from the inferior colliculus in man. Electroencephalogr Clin Neurophysiol 53:612–620
Moller AR, Jannetta P, Bennett M, Moller MB (1981) Intracranially recorded responses from the human auditory nerve: new insights into the origin of brain stem evoked potentials (BSEPs). Electroenceph Clin Neurophysiol 52:18–27
Narayan RK, Greenberg RP, Miller JD, Enas GG, Choi SC, Kishore PRS, Seihorst JB, Lutz III HA, Becker DP (1981) Improved confidence of outcome prediction in severe head injury: a comparative analysis of the clinical examination, multimodality evoked potentials, CT scanning, and intracranial pressure. J Neurosurg 54:751–762
O-Uchi T, Igarashi M, Kulecz WB (1982) Transection of crossed olivocochlear bundle and auditory brain stem responses in the cat. Acta Otolaryngol 94:1–6
Pan CH, Chen TJ, Lin KS, Chen SS (1989) Brainstem auditory evoked potentials in head injury patients. Kaohsiung J Med Sci 5:569–577
Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, Sydney
Plantz RG, Williston JS, Jewett DL (1974) Spatio-temporal distribution of auditory-evoked far field potentials in rat and cat. Brain Res 68:55–71
Shaw NA (1988) The auditory evoked potentials in the rat — a review. Prog Neurobiol 31:19–45
Starr A, Achor LJ (1975) Auditory brainstem responses in neurological diseases. Arch Neurol 32:761–768
Starr A, Hamilton AE (1976) Correlation between confirmed sites of neurological lesions and abnormalities of far-field auditory brainstem responses. Electroencephalogr Clin Neurophysiol 41:595–608
Wada SI, Starr A (1983a) Generation of auditory brain stem responses (ABRs). I. Effects of injection of a local anesthetic (procaine HC1) into the trapezoid body of guinea pigs and cat. Electroencephalogr Clin Neurophysiol 56:326–339
Wada SI, Starr A (1983b) Generation of auditory brain stem responses (ABRs). II. Effects of surgical section of the trapezoid body on the ABR in guinea pigs and cat. Electroencephalogr Clin Neurophysiol 56:340–351
Wada SI, Starr A (1983c) Generation of auditory brain stem responses (ABRs). III. Effects of lesions of the superior olive, lateral lemniscus and inferior colliculus on the ABR in guinea pig. Electroencephalogr Clin Neurophysiol 56:352–366
Wiederhold ML (1970) Variations in the effects of electric stimulation of the crossed olivocochlear bundle on cat single auditorynerve-fiber responses to tone bursts. J Acoust Soc Am 48:966–977
Wiederhold ML, Kiang NYS (1970) Effects of electric stimulation of the crossed olivocochlear bundle on single auditory-nerve fibers in the cat. J Acoust Soc Am 48:950–965
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chen, TJ., Chen, SS. Generator study of brainstem auditory evoked potentials by a radiofrequency lesion method in rats. Exp Brain Res 85, 537–542 (1991). https://doi.org/10.1007/BF00231737
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00231737