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Atrial natriuretic peptide during and after maximal and submaximal exercise under normoxic and hypoxic conditions

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Summary

The present study was designed to investigate the influence of exercise intensity and duration as well as of inspiratory oxygen content on plasma atrial natriuretic peptide concentration ([ANP]) and furthermore to compare ANP with the effect on aldosterone concentration ([Aldo]). Ten untrained male subjects performed a maximal exercise test (ME) on a cycle ergometer and a submaximal test of 60-min duration at 60% of maximal performance (SE) under normoxia (N) and normobaric hypoxia (H) (partial pressure of oxygen: 12.3 kPa). Five subjects were exposed to hypoxia at rest for 90 min. The [ANP] was mostly affected by exercise intensity (5 min after ME-N, +298.1%, SEM 39.1%) and less by exercise duration (at the end of SE-N: +229.5%, SEM 33.2%). Hypoxia had no effect at rest and reduced the exercise response (ME-H, +184.3%, SEM 27.2%; SE-H, +172.4%, SEM 15.7%). In contrast to ANP, the Aldo response was affected more by duration at submaximal level (+290.1%, SEM 34.0%) than by short maximal exercise (+235.7%, SEM 22.2%). Exposure to hypoxia rapidly decreased [Aldo] (−28.5%, SEM 3.7% after 30 min, P<0.01), but did not influence the exercise effects (ME-H, +206.2%, SEM 26.4%; SE-H, +321.6%, SEM 51.6%). The [ANP] increase was faster than that of [Aldo] during the maximal tests and there was no difference during submaximal exercise. Changes in plasma volume (PV), sodium concentration, and osmolality (Osm) were most pronounced during maximal exercise (for ME-N: PV −13.1%, SD 3.6%, sodium +6.2 mmol·1−1, SD 2.7, Osm +18.4 mosmol·kg H2O−1, SD 6.5). Regression analysis showed high correlations between changes in [ANP] and in Osm during and after maximal exercise and between changes in [ANP] and heart rate for submaximal exercise. It is concluded that besides other mechanisms increased Osm might be involved in the exercise-dependent increase of plasma [ANP].

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Authors and Affiliations

  1. Abteilung für Sport- und Arbeitsphysiologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, D-3000, Hannover 61, Germany

    W. Schmidt, S. Strauch & A. Hilgendorf

  2. Abteilung für klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, D-3000, Hannover 61, Germany

    G. Brabant & C. Kröger

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  1. W. Schmidt
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  2. G. Brabant
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  4. S. Strauch
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Schmidt, W., Brabant, G., Kröger, C. et al. Atrial natriuretic peptide during and after maximal and submaximal exercise under normoxic and hypoxic conditions. Europ. J. Appl. Physiol. 61, 398–407 (1990). https://doi.org/10.1007/BF00236059

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