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Inhibitory interactions contributing to the ocular dominance of monocularly dominated cells in the normal cat striate cortex

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Summary

Experiments have been carried out to ascertain whether intracortical inhibitory processes influence the ocular dominance of monocularly dominated cells in the primary visual cortex of the normal cat. The GABA antagonist bicuculline has been iontophoretically applied to the cells studied to produce a localised block of inhibitory mechanisms acting on them. The ocular dominance of these cells was tested before, during, and after bicuculline application.

In a sample of 42 cells studied, approximately 50% (19) showed a significant change in ocular dominance during bicuculline application. Some exclusively monocular cells became equally driven by either eye during bicuculline application. All the effects were reversible. Receptive field properties revealed in the non-dominant eye were not identical to those in the dominant eye.

Evidence is presented to suggest that for some of the cells there is a selective GABA-mediated inhibitory process suppressing the non-dominant eye input. The possible implications of these data are discussed.

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References

  • Barlow HB, Blakemore C, Pettigrew JD (1967) The neural mechanisms of binocular depth discrimination. J Physiol (Lond) 193: 327–342

    Google Scholar 

  • Bishop PO, Coombs JS, Henry GH (1971) Responses to visual contours. Spatio-temporal aspects of excitation in the receptive fields of simple striate neurones. J Physiol (Lond) 219: 625–657

    Google Scholar 

  • Blakemore C, Garey LJ, Vital Durand F (1978) The physiological effects of monocular deprivation and their reversal in the monkey's visual cortex. J Physiol (Lond) 283: 223–262

    Google Scholar 

  • Creutzfeldt OD, Ito M (1968) Functional synaptic organisation of primary visual cortex neurones in the cat. Exp Brain Res 6: 324–352

    Google Scholar 

  • Creutzfeldt OD, Kuhnt U, Benevento LA (1974) An intracellular analysis of visual cortical neurones response to moving stimuli. Response in cooperative neuronal network. Exp Brain Res 21: 251–274

    Google Scholar 

  • Creutzfeldt OD, Garey LJ, Kuroda R, Wolff JR (1977) The distribution of degenerating axons after small lesions in the intact and isolated visual cortex of the cat. Exp Brain Res 27: 419–440

    Google Scholar 

  • Duffy FH, Snodgrass SR, Burchfiel JL, Conway JL (1976) Bicuculline reversal of deprivation amblyopia in the cat. Nature 260: 256–257

    Google Scholar 

  • Fernald R, Chase R (1971) An improved method for plotting retinal land marks and focussing the eyes. Vision Res 11: 95–96

    Google Scholar 

  • Ferster D, Le Vay S (1978) The axonal arborization of lateral geniculate neurons in the striate cortex of the cat. J Comp Neurol 182: 923–944

    Google Scholar 

  • Fisken RA, Garey LJ Powell TPS (1975) The intrinsic association and commissural connections of area 17 of the visual cortex. Proc R Soc Lond [Biol] 272: 487–536

    Google Scholar 

  • Gent JP, Mayne R, Sillito AM, West DC (1976) The use of glass fibres for filling multibarrel micropipettes. J Physiol (Lond) 256: 66P

  • Gilbert CD (1977) Laminar differences in receptive field properties of cells in cat primary visual cortex. J Physiol (Lond) 268: 391–422

    Google Scholar 

  • Hammond P (1979) Stimulus dependence of ocular dominance of complex cells in area 17 of the feline visual cortex. Exp Brain Res 35: 583–589

    Google Scholar 

  • Hellon RF (1971) The marking of electrode tip positions in nervous tissue. J Physiol (Lond) 214: 12P

  • Hess R, Ostendorf D, Sanides D, Negishi K, Creutzfeldt OD (1976) Neuronal connections in the visual cortex as revealed by intracortical chemical stimulation. Exp Brain Res [Suppl] 1: 384–388

    Google Scholar 

  • Hubel DH, Wiesel TN (1962) Receptive fields, binocular interaction, and functional architecture in the cat's visual cortex. J Physiol (Lond) 160: 106–154

    Google Scholar 

  • Hubel DH, Wiesel TN (1972) Laminar and columnar distribution of geniculocortical fibres in the macaque monkey. J Comp Neurol 146: 421–450

    Google Scholar 

  • Hubel DH, Wiesel TN (1977) Functional architecture of macaque monkey visual cortex. Proc R Soc Lond [Biol] 198: 1–59

    Google Scholar 

  • Hubel DH, Wiesel TN, Le Vay S (1977) Plasticity of ocular dominance columns in monkey striate cortex. Philos Trans R Soc Lond [Biol] 278: 131–163

    Google Scholar 

  • Hubel DH, Wiesel TN, Stryker MP (1978) Anatomical demonstration of orientation columns in macaque monkey. J Comp Neurol 177: 361–380

    Google Scholar 

  • Iversen LL, Mitchell JF, Srinivasan V (1971) The release of γ- amino-butyric acid during inhibition in the cat visual cortex. J Physiol (Lond) 212: 519–534

    Google Scholar 

  • Kratz KE, Spear PD, Smith DC (1976) Postcritical period reversal of effects of monocular deprivation on striate cortex cells in the cat. J Neurophysiol 39: 501–511

    Google Scholar 

  • Le Vay S, Hubel DH, Wiesel TN (1975) The pattern of ocular dominance columns in macaque visual cortex revealed by a reduced silver stain. J Comp Neurol 159: 559–576

    Google Scholar 

  • Le Vay S, Gilbert CD (1976) Laminar patterns of geniculocortical projection in the cat. Brain Res 112: 1–19

    Google Scholar 

  • Lund JS, Boothe RG (1975) Interlaminar connections and pyramidal neurone organisation on the visual cortex, Area 17, of the macaque monkey. J Comp Neurol 139: 305–334

    Google Scholar 

  • Lund JS, Henry GH, Macqueen CL, Harvey AR (1979) Anatomical organisation of the primary visual cortex (Area 17) of the cat. A Comparison with area 17 of the macaque monkey. J Comp Neurol 184: 599–618

    Google Scholar 

  • Movshon JA (1975) The velocity tuning of single units in cat striate cortex. J Physiol (Lond) 249: 445–468

    Google Scholar 

  • Patel HH, Sillito AM (1978) Inhibition and the normal ocular dominance distribution in cat visual cortex. J Physiol (Lond) 280: 48–49P

    Google Scholar 

  • Patel HH, Sillito AM (1978) Inhibition and velocity tuning in the cat visual cortex. J Physiol (Lond) 284: 113–114P

    Google Scholar 

  • Pettigrew JD, Nikara T, Bishop PO (1968) Binocular interaction on single units in cat striate cortex. Simultaneous stimulation by single moving slit with receptive fields in correspondence. Exp Brain Res 4: 391–410

    Google Scholar 

  • Poggio GF, Fischer B (1977) Binocular interaction and depth sensitivity in striate and prestriate cortex of behaving rhesus monkey. J Neurophysiol 40: 1392–1405

    Google Scholar 

  • Ribak CE (1978) Aspinous and sparsely-spinous stellate neurones in the visual cortex of rats contain glutamic acid decarboxylases. J Neurocytol 7: 461–478

    Google Scholar 

  • Rose D (1977) Response of single units in cat visual cortex to moving bars of light as a function of bar length. J Physiol (Lond) 271: 1–25

    Google Scholar 

  • Schatz CJ, Stryker MP (1978) Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation. J Physiol (Lond) 281: 267–283

    Google Scholar 

  • Schiller PH, Finlay BL, Volman SF (1976) Quantitative studies of single cell properties in monkey striate cortex. 1. Spatiotemporal organisation of receptive fields. J Neurophysiol 39: 1288–1319

    Google Scholar 

  • Sherman SM, Watkins DW, Wilson JR (1976) Further differences in receptive field properties of simple and complex cells in cat striate cortex. Vision Res 16: 919–927

    Google Scholar 

  • Sillito AM (1975a) The effectiveness of bicuculline as an antagonist of GABA and visually evoked inhibition in the cat's striate cortex. J Physiol (Lond) 250: 287–304

    Google Scholar 

  • Sillito AM (1975b) The contribution of inhibitory mechanisms to the receptive field properties of neurones in the striate cortex of the cat. J Physiol (Lond) 250: 305–329

    Google Scholar 

  • Sillito AM (1976) A simple optimal projection system for visual neurophysiology. J Physiol (Lond) 256: 65–66

    Google Scholar 

  • Sillito AM (1977) Inhibitory processes underlying the directional specificity of simple, complex and hypercomplex cells in the cats visual cortex. J Physiol (Lond) 271: 699–720

    Google Scholar 

  • Sillito AM (1979) Inhibitory mechanisms influencing complex cell orientation selectivity and their modification at high resting discharge levels. J Physiol (Lond) 289: 33–53

    Google Scholar 

  • Singer W, Tretter F, Cynader M (1975) Organisation of cat striate cortex. A correlation of receptive field properties with afferent and efferent connections. J Neurophysiol 38: 1080–1098

    Google Scholar 

  • Szentagothai J (1975) The ‘module-concept’ in cerebral architecture. Brain Res 95: 475–596

    Article  CAS  PubMed  Google Scholar 

  • Tsumoto T, Eckart W, Creutzfeldt OD (1979) Modification of orientation sensitivity of cat visual cortex neurones by removal of GABA mediated inhibition. Exp Brain Res 34: 351–363

    Google Scholar 

  • Wiesel TN, Hubel DH (1963) Single cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26: 1003–1017

    Google Scholar 

  • Wiesel TN, Hubel DH, Lam DMK (1974) Autoradiographic demonstration of ocular dominance columns in the monkey striate cortex by means of transneuronal transport. Brain Res 79: 273–279

    Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Medical School, B15 2TJ, Birmingham, England

    A. M. Sillito, J. A. Kemp & H. Patel

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  1. A. M. Sillito
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  2. J. A. Kemp
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  3. H. Patel
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The support of the Wellcome Trust is gratefully acknowledged

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Sillito, A.M., Kemp, J.A. & Patel, H. Inhibitory interactions contributing to the ocular dominance of monocularly dominated cells in the normal cat striate cortex. Exp Brain Res 41, 1–10 (1980). https://doi.org/10.1007/BF00236673

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  • DOI: https://doi.org/10.1007/BF00236673

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