Skip to main content
Log in

Contrast-enhanced fat saturation magnetic resonance imaging for studying the pathophysiology of osteonecrosis of the hips

  • Articles
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

We imaged 75 hips in 40 patients using fat saturation technique before and after intravenous injection of contrast (0.1 mmol/kg gadolinium diethylene triamine penta-acetic acid, Gd-DTPA). Eighteen hips in 11 patients were determined to be osteonecrotic, either by pathologic or clinical examination. In the osteonecrotic hips, three distinct patterns of enhancement were found: (I) focal area outlined by brightly enhancing rim (7 hips); (II) diffuse enhancement in the femoral head and neck extending into the femoral shaft (3 hips); and (III) a combination of patterns I and II (8 hips). Our data support the hypothesis that early nontraumatic osteonecrosis is associated with hyperemia and/or an increase in capillary permeability rather than acute devascularization, and that diffuse marrow edema is the initial finding in early nontraumatic osteonecrosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Armitage FE, Richardson DE, Li KCP (1990) Polymeric contrast agents for magnetic resonance imaging: synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to polysaccharides. Bioconjug Chem 1:365

    Google Scholar 

  2. Beltran J, Chandnani V, McGhee RA Jr, Kursunoglu-Brahme S (1991) Gadopentetate dimeglumine-enhanced MR imaging of the musculoskeletal system. AJR 156:457

    Google Scholar 

  3. Coleman BG, Kressel HY, Dalinka MK, Scheibler ML, Burk DL, Cohen EK (1988) Radiographically negative avascular necrosis: detection in high-risk patients with MR imaging. Radiology 168:525

    Google Scholar 

  4. Cova M, Kang YS, Tsukamoto H, et al. (1991) Bone marrow perfusion evaluated with gadolinium-enhanced dynamic fast MR imaging in a dog model. Radiology 179:535

    Google Scholar 

  5. Genez BM, Wilson MR, Houk RW, et al. (1988) Early osteonecrosis of the femoral head: detection in high-risk patients with MR imaging. Radiology 168:521

    Google Scholar 

  6. Keller PJ, Hunter WW, Schmalbrock P (1987) Multisection fat-water imaging with chemical shift selective presaturation. Radiology 164:539

    Google Scholar 

  7. Kopecky KK, Braunstein EM, Brandt KD, et al. (1991) Apparent avascular necrosis of the hip: appearance and spontaneous resolution of MR findings in renal allograft recipients. Radiology 179:523

    Google Scholar 

  8. Kramer J, Hoffman S Jr, Engel A Jr, Neuhold A Jr, Leder K Jr, Imhof H (1991) Bone marrow edema in transient osteoporosis: initial stage of avascular necrosis of the hip. Radiology 181(P):136

    Google Scholar 

  9. Mitchell DG (1989) Using MR imaging to probe the pathophysiology of osteonecrosis. Radiology 171:25

    Google Scholar 

  10. Mitchell DG, Rao VM, Dalinka MD, et al. (1987) Avascular necrosis of the femoral head: correlation of MR imaging, radiographic staging, radionuclide imaging, and clinical findings. Radiology 162:709

    Google Scholar 

  11. Schmiedl U, Ogan M, Paajanen H, et al. (1987) Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies. Radiology 162:205

    Google Scholar 

  12. Semelka RC, Chew W, Hricak H, Tomei E, Higgins CB (1990) Fat-saturation MR imaging of the upper abdomen. AJR 155:1111

    Google Scholar 

  13. Simon JH, Szumowski J (1989) Chemical shift imaging with paramagnetic contrast material enhancement for improved lesion depiction. Radiology 171:539

    Google Scholar 

  14. Turner DA, Templeton AC, Selzer PM, Rosenberg AG, Petasnick JP (1989) Femoral capital osteonecrosis: MR findings of diffuse marrow abnormalities without focal lesions. Radiology 171:135

    Google Scholar 

  15. Wang S, Wilkstrom MG, White DL, et al. (1990) Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent: imaging characteristics in normal rat tissues. Radiology 175:483

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, K.C.P., Hiette, P. Contrast-enhanced fat saturation magnetic resonance imaging for studying the pathophysiology of osteonecrosis of the hips. Skeletal Radiol. 21, 375–379 (1992). https://doi.org/10.1007/BF00241816

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00241816

Key words

Navigation