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An investigation of collateral projections of the dorsal lateral geniculate nucleus and other subcortical structures to cortical areas V1 and V4 in the macaque monkey: A double label retrograde tracer study

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Summary

Previous anterograde studies in the macaque monkey have shown that, in addition to the projection to striate cortex (V1), the dorsal lateral geniculate nucleus (DLG) has a sparse, horizontally segregated projection to layers IV and V of prestriate cortex (V4). However, the distribution and degree of axon collateralization of DLG cells which give rise to these projections are unknown. This study was designed to answer these questions. The DLG (along with the pulvinar and other subcortical regions) was examined for the presence of single- or doublelabeled cells after injections of two different (fluorescent or HRP) retrograde tracers into corresponding retinotopic points in visual cortical areas V1 and V4. In the DLG, it was found that cells projecting to V4, which reside in or near the tectorecipient interlaminar zones of the DLG, do not project to V1 and thus represent a separate population of cells. The organization of the macaque geniculo-prestriate projection thus seems quite different from that of carnivores. Both single- and double-labeled cells were found in other subcortical areas, e.g., single-labeled cells were found in the claustrum, hypothalamus and lateral pulvinar, and a double-labeled cell population was found in the inferior pulvinar.

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Abbreviations

BSC:

Brachium of the superior colliculus

Cd:

Caudate nucleus

Cl:

Claustrum

DLG:

Dorsal lateral geniculate nucleus

GP:

Globus pallidus

Hce1:

Medial hypothalamic cholinesterase group of Mesulam et al. (1983)

Hce2:

Lateral hypothalamic cholinesterase group of Mesulam et al. (1983)

Hip:

Hippocampus

ot:

optic tract

PI:

Inferior pulvinar

PL:

Lateral pulvinar

PM:

Medial pulvinar

Put:

Putamen

Ret:

Reticular nucleus of thalamus

Thal:

Thalamus

v:

ventricle

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Author notes

  1. A. Lysakowski

    Present address: Committee on Neurobiology, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA

  2. G. P. Standage

    Present address: Dept. of Anatomy, Medical College of Georgia, 30912, Augusta, GA, USA

Authors and Affiliations

  1. Department of Anatomy, University of Illinois College of Medicine, P. O. Box 6998, 60680, Chicago, IL, USA

    A. Lysakowski, G. P. Standage & L. A. Benevento

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  1. A. Lysakowski
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  2. G. P. Standage
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  3. L. A. Benevento
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Lysakowski, A., Standage, G.P. & Benevento, L.A. An investigation of collateral projections of the dorsal lateral geniculate nucleus and other subcortical structures to cortical areas V1 and V4 in the macaque monkey: A double label retrograde tracer study. Exp Brain Res 69, 651–661 (1988). https://doi.org/10.1007/BF00247317

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