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Severe vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy

  • Original Articles
  • Vinblastine, Bleomycin, Cisplatin Vascular Toxicity, Chemotherapy
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Summary

Vascular toxicity following the use of vinblastine, bleomycin, and cisplatin (VBP) combination chemotherapy has been described. This report gives details of 5 patients who suffered acute life-threatening vascular events following such a chemotherapy regimen for germ cell tumors. In 3 of the cases no evidence of tumor was found at autopsy. Both an acute and a long-term vascular toxicity were seen. Large artery vascular disease may result from synergistic toxicity of the drugs comprising the regimen. These cases, with an additional 16 collected from the literature, suggest that major vascular disease is a significant side-effect of the VBP regimen.

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References

  1. Bodensteiner DC (1981) Fatal coronary artery fibrosis after treatment with bleomycin, vinblastine, and cis-platinum. South Med J 74: 898

    Google Scholar 

  2. Chernicoff DP, Bukowski RM, Young JR (1978) Raynaud's phenomenon after bleomycin therapy. Cancer Treat Rep 62: 570.

    Google Scholar 

  3. Cohen RJ, Cuneo RA, Cruciger MP, Jackman AE (1983) Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin. J Clin Oncol 1: 392

    Google Scholar 

  4. Comis RL, Kuppinger MS, Ginsberg SJ, Crooke ST, Gilbert R, Auchincloss JH, Prestayko AW (1979) Role of single breath carbon monoxide-diffusing capacity in monitoring the pulmonary effects of bleomycin in germ cell tumor patients. Cancer Res 39: 5076.

    Google Scholar 

  5. Doll DC, Ringenberg QS, Yarbro JW (1986) Vascular toxicity associated with antineoplastic agents. J Clin Oncol 4: 1405.

    Google Scholar 

  6. Drasga RE, Einhorn LH, Williams SD (1982) The chemotherapy of testicular cancer. CA 32: 66

    Google Scholar 

  7. Dunagin WG (1983) Clinical toxicity of chemotherapeutic agents: dermatologic toxicity. Semin Oncol 9: 14.

    Google Scholar 

  8. Edwards GS, Lane M, Smith FE (1979) Long-term treatment with cis-dichlorodiammineplatinum (II)-vinblastine-bleomycin: possible association with severe coronary artery disease. Cancer Treat Rep 63: 551.

    Google Scholar 

  9. Einhorn LH, Donohue J (1977) cis-Diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87: 293.

    Google Scholar 

  10. Griest A, Roth B, Einhorn L, Williams S (1985) Cisplatin combination chemotherapy for disseminated germ cell tumors: long-term followup. (Abstract) Proc Am Soc Clin Oncol 4: C-388.

  11. Harrell RM, Sibley R, Vogelzang NJ (1982) Renal vascular lesions after chemotherapy with vinblastine, bleomycin, and cisplatin. Am J Med 73: 429.

    Google Scholar 

  12. Iseri LT, Freed J, Bures AR (1975) Magnesium deficiency and cardiac disorders. Am J Med 58: 837.

    Google Scholar 

  13. Kahaleh MB, Osborn I, LeRoy EC (1981) Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and Raynaud's phenomenon. Ann Intern Med 94: 482.

    Google Scholar 

  14. Kukla LJ, Burrows D, Bressler L, McGuire WP, (1981) Bleomycin-induced Raynaud's phenomenon. Arch Dermatol 117: 604.

    Google Scholar 

  15. Kukla LJ, McGuire WP, Lad T, Saltiel M (1982) Acute vascular episodes associated with therapy for carcinomas of the upper aerodigestive tract with bleomycin, vincristine and cisplatin. Cancer Treat Rep 66: 369.

    Google Scholar 

  16. Lejonc JL, Vernant JP, Macquin I, Castaigne A (1980) Myocardial infarction following vinblastine treatment. Lancet II: 692.

    Google Scholar 

  17. Licciardello J, Moake J, Rudy C, Karp D, Hong W (1984) Increased von Willebrand factor antigen and vascular toxicity following cisplatin-based combination chemotherapy. (Abstract) Proc Am Soc Clin Oncol 3: 122C.

  18. Pui C-H, Chesney CM, Weed J, Jackson CW (1985) Altered von Willebrand factor molecule in children with thrombosis following asparaginase-prednisone-vincristine therapy for leukemia. J Clin Oncol 3: 1266.

    Google Scholar 

  19. Redman JR, Vugrin D, Zalman AA, Gee TS, Kempin SJ, Godbold JH, Schottenfeld D, Clarkson BD (1984) Leukemia following treatment of germ cells tumors in men. J Clin Oncol 2: 1080.

    Google Scholar 

  20. Schaeppi U, Thompson GR, Fleishman RW, Baker JR, Rosenkrantz H, Ilievski V, Cooney DA, Davis RD (1973) Preclinical toxicologic evaluation of bleomycin in thesus monkeys. Cancer Chemother Rep [3] 4: 31

    Google Scholar 

  21. Schilsky RL, Barlock A, Ozols RF (1982) Persistent hypomagnesemia following cisplatin chemotherapy for testicular cancer. Cancer Treat Rep 66: 1767.

    Google Scholar 

  22. Smith EA, Harper FE, LeRoy EC (1985) Raynaud's phenomenon of a single digit following local intradermal bleomycin sulphate injection. Arthritis Rheum 28: 459.

    Google Scholar 

  23. Somers G, Abramow M, Wittek M, Naets JP (1976) Myocardial infarction: a complication of vincristine treatment. Lancet II: 690.

    Google Scholar 

  24. Teutsch C, Lipton A, Harvey HA (1977) Raynaud's phenomenon as a side effect of chemotherapy with vinblastine and bleomycin for testicular cancer. Cancer Treat Rep 61: 925.

    Google Scholar 

  25. Turlapaty PDMV, Altura BM (1980) Magnesium deficiency produces spasm of coronary arteries: relationship to etiology of sudden death eschemic heart disease. Science 208: 198.

    Google Scholar 

  26. Vogelzang NJ, Frenning DH, Kennedy BJ (1980) Coronary artery disease after treatment with bleomycin and vinblastine. Cancer Treat Rep 64: 1159.

    Google Scholar 

  27. Vogelzang NJ, Bosl GJ, Johnson K, Kennedy BJ (1981) Raynaud's phenomenon: a common toxicity after combination chemotherapy for testicular cancer. Ann Intern Med 95: 288.

    Google Scholar 

  28. Vogelzang NJ, Torkelson JL, Kennedy BJ (1985) Hypomagnesemia, renal dysfunction and Raynaud's phenomenon in patients treated with cisplatin, vinblastine, and bleomycin. Cancer 56: 2765.

    Google Scholar 

  29. Vugrin D, Herr HW, Whitmore WF, Sogani PC, Golbey RB (1981) VAB-6 combination chemotherapy in disseminated cancer of the testis. Ann Intern Med 95: 59.

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, Ill, USA

    Brian L. Samuels & Nicholas J. Vogelzang

  2. Department of Medicine, Section of Medical Oncology, University of Minnesota, Minneapolis, Minn, USA

    B. J. Kennedy

Authors
  1. Brian L. Samuels
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  2. Nicholas J. Vogelzang
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  3. B. J. Kennedy
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Additional information

Supported by the Jazz and Blues Fund and by the Deborah Goldfine Reva Smilgoff Memorial Fund. Brian Samuels is the Triangle Industries Cancer Research Fellow

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Samuels, B.L., Vogelzang, N.J. & Kennedy, B.J. Severe vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy. Cancer Chemother. Pharmacol. 19, 253–256 (1987). https://doi.org/10.1007/BF00252982

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  • DOI: https://doi.org/10.1007/BF00252982

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