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Cumulative renal tubular damage associated with cisplatin nephrotoxicity

  • Original Articles
  • Cisplatin Nephrotoxicity
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Summary

We assessed the acute and chronic effect of multiple courses of cisplatin therapy on renal tubules by monitoring the urinary excretion of alanine aminopeptidase, N-acetyl-β-D-glucosaminidase, and total protein. Urine specimens were obtained before and after doses of cisplatin (90 mg/m2) given to 12 patients. Each dose of cisplatin induced transient increases in enzyme excretion, followed by proteinuria 3–5 days later. Transient enzymuria after the last cisplatin dose was significantly greater than that after the first dose. Moreover, persistent increases in urinary N-acetyl-β-D-glucosaminidase and serum creatinine concentrations over pretherapy levels indicated chronic renal tubular damage. Our findings disclosed striking differences between patients in susceptibility to progressive nephrotoxicity.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, St Jude Children's Research Hospital, 38101, Memphis, TN, USA

    Marshall P. Goren & Reba K. Wright

  2. Department of Hematology-Oncology, St Jude Children's Research Hospital, 38101, Memphis, TN, USA

    Marc E. Horowitz

Authors
  1. Marshall P. Goren
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  2. Reba K. Wright
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  3. Marc E. Horowitz
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Additional information

Supported by Biomedical Research Support Grant RR05584 (MPG), Cancer Center Support Grant (CORE) CA-21765, Chilhood Solid Tumor Program Project Grant CA-23099 and the American Lebanese Syrian Associated Charities (ALSAC)

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Goren, M.P., Wright, R.K. & Horowitz, M.E. Cumulative renal tubular damage associated with cisplatin nephrotoxicity. Cancer Chemother. Pharmacol. 18, 69–73 (1986). https://doi.org/10.1007/BF00253068

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  • DOI: https://doi.org/10.1007/BF00253068

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