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Comparative metabolism and excretion of adriamycin in man, monkey, and rat

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  • Adriamycin
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Summary

Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.

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Author notes

  1. P. M. Wilkinson

    Present address: Christie Hospital, Wilmslow Road, 20, Manchester, England

Authors and Affiliations

  1. Division of Medicinal Chemistry and Pharmacology, Sidney Farber Cancer Institute, Harvard Medical School, 35 Binney Street, 02115, Boston, Massachusetts, USA

    P. M. Wilkinson, M. Israel, W. J. Pegg & E. Frei III

Authors
  1. P. M. Wilkinson
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  2. M. Israel
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  3. W. J. Pegg
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  4. E. Frei III
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Wilkinson, P.M., Israel, M., Pegg, W.J. et al. Comparative metabolism and excretion of adriamycin in man, monkey, and rat. Cancer Chemother. Pharmacol. 2, 121–125 (1979). https://doi.org/10.1007/BF00254084

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  • DOI: https://doi.org/10.1007/BF00254084

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