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Study of histamine release induced by acute administration of antitumor agents in dogs

  • Original Articles
  • Antitumor Agents, Histamine Release
  • Published:
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Summary

The effects of eight antitumoral drugs known to cause anaphylactoid side effects in clinical use were studied in dogs. Blood pressure, heart rate, and blood and plasma histamine levels were monitored. L-asparaginase, methotrexate, 5-fluorouracil, bleomycin, and cisplatin had no effect on these parameters. Doxorubicin, Vehem (teniposide), and Vepeside (etoposide) induced hypotension, tachycardia, and a rise in histamine levels. In the cases of Vehem and Vepeside, the excipient (respectively, cremophor EL and tween 80) induced the same effects. These agents, like elliptinium, which had been previously studied, induce nonspecific histamine release — unlike the other drugs studied. The mechanism of clinically observed anaphylactoid side effects is discussed in the light of these findings.

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Authors and Affiliations

  1. Department of Pharmacology, INSERM U195, Faculty of Medicine, F-63001, Clermont-Ferrand Cédex, France

    Alain Eschalier, Jeannine Lavarenne, Monique Renoux, Eric Chapuy & Maria Rodriguez

  2. INSERM U200, Faculty of Medicine Necker Enfants Malades, 175 rue de Vaugirard, F-75015, Paris, France

    Claude Burtin

Authors
  1. Alain Eschalier
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  2. Jeannine Lavarenne
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  3. Claude Burtin
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  4. Monique Renoux
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  5. Eric Chapuy
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  6. Maria Rodriguez
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Eschalier, A., Lavarenne, J., Burtin, C. et al. Study of histamine release induced by acute administration of antitumor agents in dogs. Cancer Chemother. Pharmacol. 21, 246–250 (1988). https://doi.org/10.1007/BF00262779

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  • DOI: https://doi.org/10.1007/BF00262779

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