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Constitutional Robertsonian T(15;22) in Ph-positive CML

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Summary

Chromosome studies in a phenotypically normal 40-year-old man with Philadelphia (Ph) chromosome-positive chronic myelocytic leukemia (CML) and a constitutional Robertsonian translocation are reported. The possibility of carriers of Robertsonian translocations having an increased risk to develop Ph-positive CML is mentioned.

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References

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Authors and Affiliations

  1. Westdeutsches Tumorzentrum, Innere Universitäts- und Poliklinik (Tumorforschung), Hufelandstrasse 55, D-4300, Essen 1, Federal Republic of Germany

    Reinhard Becher & Dagmar Kühn

  2. Abreilung für Hämatologie und Onkologie, Evangelisches Krankenhaus Essen-Werden, Pattbergstrasse 1-3, D-4300, Essen, Federal Republic of Germany

    Friedrichcarl Wendt

Authors
  1. Reinhard Becher
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  2. Friedrichcarl Wendt
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  3. Dagmar Kühn
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Becher, R., Wendt, F. & Kühn, D. Constitutional Robertsonian T(15;22) in Ph-positive CML. Hum Genet 76, 399 (1987). https://doi.org/10.1007/BF00272453

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  • DOI: https://doi.org/10.1007/BF00272453

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