Summary
Alterations of HLA class I genes were found in 3 of 12 human colon cancers. Rearrangements in HLA class I genes were observed in 2 cancers and amplification of HLA-coding genes was observed in 1 cancer. All 3 cancers were at an advanced stage. No examples of amplification or rearrangement in the HLA genes were found in 10 other tumours of diverse types. No alterations in the β2-microgubulin gene were observed in 22 human solid tumours included in this study. The association between alterations in HLA genes and proto-oncogenes in these tumours is discussed.
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Bar-Eli, M., Battifora, H. & Cline, M.J. Alterations of class I HLA genes in human colon cancers. Hum Genet 78, 86–89 (1988). https://doi.org/10.1007/BF00291242
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DOI: https://doi.org/10.1007/BF00291242