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Analysis of mammalian MUC1 genes reveals potential functionally important domains

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References

  • Bazan, J.F. (1990). Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87, 6934–6938.

    Google Scholar 

  • Braga, V.M.M., Pemberton, L.F., Duhig, T., Gendler, S.J. (1992). Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development. Development 115, 427–437.

    Google Scholar 

  • Chirgwin, J.M., Przybyla, A.E., MacDonald, R.J., Rutter, W.J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294–5299.

    Google Scholar 

  • Gendler, S.J., Lancaster, C.A., Taylor-Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Lalani, E-N., Wilson, D. (1990). Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J. Biol. Chem. 265, 15286–15293.

    Google Scholar 

  • Hunziker, W., Fumey, C., Honing, S., Kamel, L.C. (1994). Trafficking of immunoglobulin receptors in epithelial cells: signals and cellular factors. Cell. Biol. Int. 18, 321–325.

    Google Scholar 

  • Kioussis, D., Wilson, F., Daniels, C., Leveton, C., Taverne, J., Playfair, J.H.L. (1987). Expression and rescuing of a cloned human necrosis factor gene using an EBV-based shuttle cosmid vector. EMBO J. 6, 355–361.

    Google Scholar 

  • Ligtenberg, M.J.L., Kruijshaar, L., Buijs, F., van Meijer, M., Litvinov, S.V., Hilkens, J. (1992). Cell-associated episialin is a complex containing two proteins derived from a common precursor. J. Biol. Chem. 267, 6171–6177.

    Google Scholar 

  • Maniatis, T., Fritsch, E.F., Sambrook, J. (1982). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, N.Y.: Cold Spring Harbor, Laboratory Press), pp. 65–67.

    Google Scholar 

  • Marchuk, D., Drumm, M., Saulino, A., Collins, F.S. (1991). Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res. 19, 1154.

    Google Scholar 

  • Patton, S., Patton, R.S. (1990). Genetic polymorphism of PAS-I, the mucin-like glycoprotein of bovine milk fat globule membrane. J. Dairy Sci. 73, 3567–3574.

    Google Scholar 

  • Patton, S., Huston, G.E., Jennes, R., Vaucher, Y. (1989). Differences between individuals in high-molecular-weight glycoproteins from mammary epithelia of several species. Biochim. Biophys. Acta 980, 333–338.

    Google Scholar 

  • Pelham, H.R. (1990). The retention signal for soluble proteins of the endoplasmic reticulum. Trends Biochem. Sci. 15, 483–486.

    Google Scholar 

  • Pemberton, L., Taylor-Papadimitriou, J., Gendler, S.J. (1992). Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals. Biochem. Biophys. Res. Commun. 185, 167–175.

    Google Scholar 

  • Songyang, Z., Shoelson, S.E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W.G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R.J., Neel, B.G., Birge, R.B., Fajardo, J.E., Chou, M.M., Hanafusa, H., Schaffhausen, B., Cantley, L.C. (1993). SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767–778.

    Google Scholar 

  • Spicer, A.P., Parry, G., Patton, S., Gendler, S.J. (1991). Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism. J. Biol. Chem. 266, 15099–15109.

    Google Scholar 

  • Swallow, D.M., Gendler, S., Griffiths, B., Corney, G., Taylor-Papadimitriou, J., Bramwell, M.E. (1987). The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM. Nature 327, 82–84.

    Google Scholar 

  • Taylor-Papadimitriou, J. (1991). Report on the first international workshop on carcinoma-associated mucins. Int. J. Cancer 49, 1–5.

    Google Scholar 

  • Turner, J.M., Brodsky, M.H., Irving, B.A., Levin, S.D., Perlmutter, R.M., Littman, D.R. (1990). Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60, 755–765.

    Google Scholar 

  • Vos, H.L., Devries, Y., Hilkens, J. (1991). The mouse episialin (Muc-1) gene and its promoter-rapid evolution of the repetitive domain in the protein. Biochem. Biophys. Res. Commun. 181, 121–130.

    Google Scholar 

  • Zrihan-Licht, S., Vos, H.L., Baruch, A., Elroy-Stein, O., Sagiv, D., Keydar, I., Hilkens, J., Wreschner, D.H. (1994a). Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue. Eur. J. Biochem. 224, 787–795.

    Google Scholar 

  • Zrihan-Licht, S., Baruch, A., Elroy-Stein, O., Keydar, I., Wreschner, D.H. (1994b). Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins cytokine receptor-like molecules. FEBS Lett. 356, 130–136.

    Google Scholar 

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Spicer, A.P., Duhig, T., Chilton, B.S. et al. Analysis of mammalian MUC1 genes reveals potential functionally important domains. Mammalian Genome 6, 885–888 (1995). https://doi.org/10.1007/BF00292441

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