Abstract
As assessed by urine pyridinium cross-links, bone resorption increases at night. This has been ascribed to either the nocturnal rise of serum parathyroid hormone (PTH) or immobilization. ICTP is the carboxyterminal telopeptide region of type I collagen in bone, cross-linked via pyridinium cross-links and liberated during the degradation of type I collagen. To study whether the nocturnal rise in bone resorption is seen also in serum type I collagen carboxyterminal telopeptide (ICTP) and whether this rise is abolished by bedtime calcium or calcitonin, nine healthy postmenopausal women participated in three 24 hour sessions. At 2200 hours, either 1 g of oral calcium or 200 IU of intranasal calcitonin or no treatment (control session) were given. The participants were recumbent from 2200 hours to 0600 hours. Like urinary pyridinolines, serum ICTP showed a clearcut nocturnal rise during the control session, increasing from 3.7±0.3 μg/liter (mean±SE) at 2000 hours to 4.9±0.4 μg/liter at 0600 hours (P<0.001). Administration of calcium did not affect either serum ICTP or urinary pyridinolines, although it decreased serum intact PTH by 18% (P<0.001) as assessed by areas under curve (AUC) after 2200 hours. Serum ICTP and urinary pyridinolines remained unchanged also after administration of calcitonin which increased the AUC for serum intact PTH by 9% (P<0.05). In conclusion, serum ICTP follows a circadian rhythm in healthy postmenopausal women. The nocturnal rise in markers of bone resorption is not due to PTH, and its dependency on the function of osteoclasts is open to question.
Similar content being viewed by others
References
(1992) Pyridinium cross-links as markers of bone resorption. (editorial) Lancet 340:278–279
Eyre D (1992) New biomarkers of bone resorption. (editorial) J Clin Endocrinol Metab 74:470A-470C
Sclemmer A, Hassager C, Jensen SB, Christiansen C (1992) Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women. J Clin Endocrinol Metab 74:476–480
Eastell R, Calvo MS, Burritt MF, Offord KP, Russell RGG, Riggs BL (1992) Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis. J Clin Endocrinol Metab 74:487–494
Jubiz W, Canterbury JM, Reiss E, Tyler FH (1972) Circadian rhythm in serum parathyroid hormone concentration in human subjects: correlation with serum calcium, phosphate, albumin, and growth hormone levels. J Clin Invest 51:2040–2046
Donaldson CL, Hylley SB, Vogel JM, Hattner S, Bayers JH, McMillan DE (1970) Effect of prolonged bed rest on bone mineral. Metabolism 19:1071–1974
Risteli J, Elomaa I, Niemi S, Novamo A, Risteli L (1993) Radioimmunoassay for the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin Chem 39:635–640
Eriksen EF, Charles P, Melsen F, Mosekilde L, Risteli L, Risteli J (1993) Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res 8:127–132
Eriksen EF, Charles P, Mosekilde L, Risteli L, Risteli J (1991) Cross-linked carboxyterminal telopeptide of type I collagen in serum: a new bone resorption marker. J Bone Miner Res 6 (suppl 1):S243
Hassager C, Risteli J, Risteli L, Jensen SB, Christiansen C (1992) Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women. J Bone Miner Res 7:1307–1311
Välimäki MJ, Tähtelä R, Jones JD, Peterson JM, Riggs BL (in press) Bone resorption in healthy and osteoporotic postmenopausal women: comparison markers for serum carboxy-terminal telopeptide of type I collagen (ICTP) and urinary pyridinium crosslinks. Eur J Endocrinol
Tohme JF, Bilezikian JP, Clemens TL, Silverberg SJ, Shane E, Lindsay R (1990) Suppression of parathyroid secretion with oral calcium in normal subjects and patients with primary hyperparathyroidism. J Clin Endocrinol Metab 70:951–956
Horowitz M, Need AG, Philcox JC, Nordin BEC (1984) Effect of calcium supplementation on urinary hydroxyproline in osteoporotic postmenopausal women. Am J Clin Nutr 39:857–859
Minaire P, Mallet E, Levernieux J, Schoutens A, Attali G, Caulin F (1987) Immobilization bone loss: preventive effect of calcitonin in several clinical models. In: Christiansen C, Riis B (eds). Osteopress, Osteoporosis 1987 Copenhagen, pp 603–610
Elias AN, Gwinup G (1992) Immobilization osteoporosis in paraplegia. J Am Paraplegia Soc 15:163–170
Chappard D, Alexandre C, Palle S, Vico L, Morukov BV, Rodionova SS, Minaire P, Riffat G (1989) Effects of a bisphosphonate (1-hydroxy ethylidene-1,1 bisphosphonic acid) on osteoclast number during prolonged bed rest in healthy humans. Metabolism 38:822–825
Thamsborg G, Skousgaard SG, Daugaard H, Schifter S, Kollerup G, Sorensen OH (1993) Acute effects of nasal salmon calcitonin on calcium and bone metabolism. Calcif Tissue Int 53:232–236
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sairanen, S., Tähtelä, R., Laitinen, K. et al. Nocturnal rise in markers of bone resorption is not abolished by bedtime calcium or calcitonin. Calcif Tissue Int 55, 349–352 (1994). https://doi.org/10.1007/BF00299313
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00299313