Summary
A 38-year-old woman suffering from primary Sjögren's syndrome for 2 years developed angiofollicular hyperplasia (multicentric Castelman's disease). In Sjögren's syndrome (SS) a number of findings indicate the presence of a B-cell hyperactivity that may evolve to a lymphoproliferative disorder. This report adds another pathological event to the complex spectrum of lymphoproliferative diseases in SS.
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Godfrey N, Simon TM, Kunishima DH, Lorber A (1983) Sjögren's syndrome with pseudolymphoma treated with chrysotherapy. J Rheumatol 10:957–960
Le Charpentier Y, Faucher JN, Ghozlan R, Delbarre F, Louvel A, Lemaigre G, Vacher-Lavenu MC, Amor B, Abelanet R (1978) Lymphadénopathie angioimmunoblastique (L.A.I) riche en cellules épithélioides révélée par un syndrome de Gougerot-Sjøgren Rapports nosologiques des “pseudo-lymphodes” du Sjøgren avec L.A.I. (a propos d'un cas d'evolution mortelle). Ann Anat Pathol 23:201–216
Talan N, Bunim JJ (1964) Development of malignant lymphoma in the course of Sjögren's syndrome. Am J Med 36:529–540
Talal N, Skoloff L, Barth WF (1967) Extrasalivary lymphoid abnormalities in Sjögren's syndrome (reticulum cell sarcoma, “pseudolymphoma”, macroglobulinemia). Am J Med 43:50–65
Shearn M, Moutsopoulos H, Swada S, Gak C (1975) Sjögren's syndrome with light chain myeloma. West J Med 123:4860497
Vitali C, Tavoni A, Simi U, Viegi G, Bombardieri S (1985) A plasma cell granuloma in a patient with Sjögren syndrome. J Rheumatol 12:1212–1214
Castleman B, Iverson L, Menendez VP (1956) Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 9:822–830
Lattes R, Pachter MR (1962) Benign lymphoid masses of probable hamartomatous nature: Analysis of 12 cases. Cancer 15:197–215
Lennert K (1979) Lymphomähnliche Lymphknotenvergrößerungen In: Stacher A, Höker P (eds) Lymphknotentumoren: Pathophysiologie, Klinik und Therapie. Urban und Schwarzenberg, München, pp 35–39
Frizzera G, Banks PM, Massarelli G, Rosai J (1983) A systemic lymphoproliferative disorder with morphologie features of Castleman's disease: Pathological findings in 15 Patients. Am J Surg Pathol 7:211–231
Keller AR, Hochholzer L, Castleman B (1972) Hyaline-vascular and plasma cell types of giant lymph node hyperplasia of the nediastimum and other locations. Cancer 29:670–683
Chisholm DM, mason DK (1968) Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol 21:656–660
Moutsopoulos H (1980) Sjögren's syndrome (sicca syndrome): current issues. Ann Intern Med 92:212–226
Weisenburger DD, Nathwani BN, Winberg CD, Rappaport H (1985) Multicentric angiofollicular lumph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol 16:162–172
Ben-Chetrit E, Flusser D, Okon E, Ackerman Z, Lubinov A (1989) Multicentric Castleman's disease associated with rheumttoid arthritis: a possible role of hepatitis B antigen. Ann Rheum Dis 48:326–330
Fox RI, Adamson TC III, Fong S, Robinson CA, Morgan EL, Robb JA, Howell FU (1983) Lymphocyte phenotype and function in pseudolymphoma associated with Sjögren's syndrome. J Clin Invest 72:52–62
Radaszkiewicz T, Hansmann M-L, Lennert K (1989) Monoclonality and polyclonality of plasma cells in Castleman' disease of the plasma cell variant. Histopathology 14:11–24
Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, Nakahata T, Kawai H, Tagoh H, Komori T, Kishimoto S, Hirano T, Kishimoto T (1989) Pathogenic significance of Interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74:1360–1367
Germanidis GS, Manoussakis MN, Tzioufas AG, Drosos AA, Aarden LA, Motsopoulos HM (1991) Interleukin 6 (IL-6) in serum of patients with primar Sjögren's syndrome and other rheumatic diseases. Clin Exp Rheumatol 9:334
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Tavoni, A., Vitali, C., Baglioni, P. et al. Multicentric Castleman's disease in a patient with primary Sjögren's syndrome. Rheumatol Int 12, 251–253 (1992). https://doi.org/10.1007/BF00301012
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DOI: https://doi.org/10.1007/BF00301012