Abstract
We present herein the case of a 64-year-old man diagnosed as having a mucoepidermoid carcinoma of the pancreas. The tumor originated in the tail of the pancreas and invaded the spleen, left adrenal gland, left kidney, and transverse colon. Liver and peritoneal metastases were also noted. Despite surgical treatment and adjuvant chemotherapy, the disease progressed rapidly and the patient died of cachexia 4 months after his initial diagnosis. Mucoepidermoid carcinoma of the pancreas is a rare entity, and is believed to be a form of adenosquamous carcinoma known as adenoacanthoma. However, in this patient, no differentiated squamous cell component could be detected. In fact, the tumor was composed of mucin-producing cells, epidermoid cells, and intermediate cells. Immunohistochemical staining for the carcinoembryonic antigen, CA19-9, and SPan-1 demonstrated a production of cancerous mucin in the epidermoid cells, suggesting that mucoepidermoid carcinoma may arise from the squamoid metaplasia of an adenocarcinoma.
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References
Stewart FW, Foote FW, Becker WF (1945) Muco-epidermoid tumors of salivary glands. Ann Surg 122:820–844
Healey WV, Perzin KH, Smith L (1970) Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer 26:368–384
Brooks B, Baandrup U (1992) Peripheral low-grade mucoepidermoid carcinoma of the lung-needle aspiration cytodiagnosis and histology. Cytopathology 3:259–265
Franz VK (1959) Tumors of the pancreas. In: Atlas of tumor pathology, Section VII, fascicles 27 and 28. American Registry of Pathology
Ohshio G, Ogawa K, Manabe T, Miyashita T, Tobe T, Hamashima Y (1987) Tumor of the pancreas (3)—Squamous cell carcinoma, adenosquamous carcinoma and mucoepidermoid carcinoma (in Japanese). Geka Chiryou (Surgical Therapy) 56:349–352
Ohtsuki Y, Yoshino T, Takahashi K, Sonobe H, Kohno K, Akagi T (1987) Electron microscopic study of mucoepidermoid carcinoma in the pancreas. Acta Pathol Jpn 37:1175–1182
Kishimoto H, Ohashi D, Iritani I, Ogawa H, Nakamura Y, Osa M, Tsuzuki H (1991) A case of pancreatic mucoepidermoid carcinoma (in Japanese with English abstract). Nippon Rinshyo Geka Igakkai Zasshi (J Jpn Soc Clin Surg) 52:2168–2172
Hayashi T, Obara O, Fukui H, Kameyama K, Nakasako T, Sakai M (1992) A case of pancreatic mucoepidermoid carcinoma (in Japanese). Geka (Surgery) 54:1244–1246
Kimura Y, Furukawa T, Akaishi S, Nakamura R, Egawa S, Shibuya K, Yamanami H, Kobari M, Matsuno S (1993) A case of mucoepidermoid carcinoma of the pancreas treated with intraoperative radiation therapy (IORT) (in Japanese with English abstract). Suizou (J Jpn Panc Soc) 8:140–146
Chung YS, Ho JJL, Kim YS, Tanaka H, Nakata B, Hiura A, Motoyoshi H, Satake K, Umeyama K (1987) The detection of human pancreatic cancer-associated antigen in the serum of cancer patients. Cancer 60:1636–1643
Hanna W, Kahn HJ (1985) Ultrastructural and immunohistochemical characteristics of mucoepidermoid carcinoma of the breast. Hum Pathol 16:941–946
Mizukami Y, Matsubara F, Hashimoto T, Haratake J, Terahata S, Noguchi M, Hirose K (1984) Primary mucoepidermoid carcinoma in the thyroid grand. Cancer 53:1741–1745
Cihak RW, Kawashima T, Steer A (1972) Adenoacanthoma (adenosquamous carcinoma) of the pancreas. Cancer 29:1133–1140
Cubilla AL, Fitzgerald PJ. (1975) Morphological patterns of primary nonendocrine human pancreas carcinoma. Cancer Res 35:2234–2248
Kaecioglu ZA, Someren A (1984) Practical surgical pathology. Health, Lexington, pp 319–320
Motojima K, Tomioka T, Kohara N, Tsunoda T, Kanematsu T (1992) Immunohistochemical characteristics of adenosquamous carcinoma of the pancreas. J Surg Oncol 49:58–62
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Onoda, N., Kang, SM., Sugano, S. et al. Mucoepidermoid carcinoma of the pancreas: Report of a case. Surg Today 25, 843–847 (1995). https://doi.org/10.1007/BF00311465
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DOI: https://doi.org/10.1007/BF00311465