Abstract
Two patients with T-cell malignancy having radiographic manifestations of generalized and localized bone demineralization are reported. One, a 53-year-old man, had marked osteoporosis and severe hypercalcemia, but no clinical evidence of leukemia throughout his illness. At autopsy there was no definite evidence of bone involvement. Histologic proof was obtained from abdominal skin which revealed “adult T-cell leukemia/lymphoma (ATLL).” The second case, a 33-year-old man, complained of arthralgia in his hands and feet; radiographs showed severe localized demineralization and pathologic fractures. Specimens of his peripheral blood, cervical lymph nodes, and bone marrow revealed ATLL cells.
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Boissonas A, Khalifa P, Sereni D, Mathiot C, Vacher-Lavenu MC, Hornych A, Cremer GA, Laroche C (1982) Hypercalcemia in large cell lymphoma. Possible role of prostaglandins E2. Ann Med Interne (Paris) 133:186
Braunstein EM, White SJ (1980) Non-Hodgkin lymphoma of bone. Radiology 135:59
Greaves MF, Verbi W, Tilley R, Lister TA, Habeshaw J, Guo H-G, Trainor CD, Robert-Guroff M, Blattner W, Reitz M, Gallo RC (1984) Human T-cell leukaemia virus (HTLV) in the United Kingdom. Int J Cancer 795:806
Greenfield GB (1980) Radiology of bone diseases. 3rd edn. JB Lippincott Co, Philadelphia, p 15
Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita K, Shirakawa S, Miyoshi I (1981) Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 78:6476
Mundy GR, Rick ME, Turcotte R, Kowalski MA (1978) Pathogenesis of hypercalcemia in lymphosarcoma cell leukemia. Role of an osteoclast activating factor-like substance and a mechanism of action for glucocorticoid therapy. Am J Med 65:600
Pear BL (1974) Skeletal manifestations of the lymphomas and leukemias Semin Roentegenol 9:229
Swerdlow SH, Habeshaw JA, Rohatiner AZS, Lister TA, Stansfeld AG (1984) Caribbean T-cell lymphoma/leukemia. Cancer 687:696
Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H (1977) Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood 50:481
Yoshida M, Miyoshi I, Hinuma Y (1982) Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79:2031
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Ohuchida, T., Nishitani, H., Kamikawaji, N. et al. “Adult T-cell leukemia/lymphoma” with bone demineralization. Skeletal Radiol 14, 194–197 (1985). https://doi.org/10.1007/BF00355562
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DOI: https://doi.org/10.1007/BF00355562