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Biochemical effects of chronic exposure to noise in man

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Summary

Biochemical parameters in 75 normal healthy male subjects exposed to intense noise of 88–107 dB(A) (6–8 h/day) for 10 to 15 years during their work situation have been monitored and compared with 35 normal unexposed subjects. Levels of free cholesterol (P<0.001), γ-globulin (P<0.01) and cortisol (P<0.01) were found to be significantly higher in the exposed subjects. Significant changes in free cholesterol also altered the ratio of free to esterified cholesterol significantly (P<0.001). The value of the A/G ratio was also lower in the exposed group. Uric acid did not show any change. The study shows that in the exposed group the esterification process of cholesterol was modified. There was an effect on pituitary-adrenal axis as well as host-defence mechanism.

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References

  1. Arguelles AE, Ibeas D, Ottone JP, Chekherdemon M (1962) Pituitary adrenal stimulation by sound of different frequencies. J Clin Endocrinol 22:846–852

    Google Scholar 

  2. Atherly GRC, Gibbons SL, Powel JA (1970) Moderate subjective stimuli: the interrelation of subjective importance and certain physiological changes. Ergonomics 13:536–545

    Google Scholar 

  3. Bowyer DE, Gresham GA (1970) Arterial lipid accumulation. In: Proceedings of the 2nd International Symposium on Atherosclerosis, Chicago, Illinois, Nov 2–5, 1969. Springer, Berlin Heidelberg New York, pp 3–5

    Google Scholar 

  4. Brandenberger G, Follenius M (1977) Failure of noise exposure to modify temporal patterns of plasma cortisol in man. Eur J Appl Physiol 36:239–246

    Google Scholar 

  5. Campbell DT, Rahe RH (1974) Serum uric acid and cholesterol variability for men aboard a Polaris submarine. Milit Med 139:462–465

    Google Scholar 

  6. Favino A, Maugeri U, Kauchtschischvili G, Robustelli Della Chuna G, Nappi G (1973) Radioimmunoassay measurements of serum cortisol, thyroxine, growth hormone and luteinizing hormone with simultaneous electroencephalographic changes during continuous noise in man. J Nucl Biol Med 17:119–122

    Google Scholar 

  7. Francesconi RP, Fine BJ, Kobrick JL (1976) Heat and stimulated high altitude: effects of biochemical indices of stress and performance. Aviat Space Environ Med 47:548–552

    Google Scholar 

  8. Friedman M, Byers SO, Brown AE (1967) Plasma lipid responses of rats and rabbits to an auditory stimulus. Am J Physiol 212:1174–1178

    Google Scholar 

  9. Hanson JD, Larson E, Snowdon CT (1976) The effects of control over high intensity noise on plasma cortisol levels in rhesus monkeys. Behav Biol 16:333–340

    Google Scholar 

  10. Henry RJ, Sobel C, Kim J (1957) A modified phosphotungstate method for the determination of uric acid and comparison with the spectrophotometric uricase method. Am J Clin Pathol 28:152–160

    Google Scholar 

  11. Horio K, Sakamoto E, Matsui K (1972) Adreno cortical responses to noise exposure. In: Joint Meeting of International Societies for Hygiene Preventive and Social Medicine, 29. Oct and 1. Nov

  12. ISO (1971) Assessment of occupational noise exposure for hearing conservation purposes. International Organization for Standardization R-1999, Geneva

  13. Ising H, Dienel D, Gunther T, Markert B (1980) Health effects of traffic noise. Int Arch Occup Environ Health 47:179–190

    Google Scholar 

  14. Jansen G (1970) Relation between temporary threshold shift and peripheral circulatory effects of sound. In: Welch BL, Welch AS (eds) Physiological effects of noise. Plenum Press, New York, pp 67–74

    Google Scholar 

  15. Jones DP (1972) Lecithin cholesterol acyl transferase (LCAT). Ann Clin Lab Sci 2:93–96

    Google Scholar 

  16. Klein PD, Dahl RM (1961) The sensitivity of cholesterol esterification to environmental stress. J Biol Chem 236:1658–1660

    Google Scholar 

  17. Manninen O, Aro S (1979) Noise induced hearing loss and blood pressure. Int Arch Occup Environ Health 42:251–255

    Google Scholar 

  18. Miller IR, Greet N, Frel YF (1973) Cholesterol exchange between surface layers and plasma proteins in bulk. A ciba foundation symposium. In: Porter R, Knight J (eds) Atherosclerosis initiating factors. Assoc Sci Publ, Amsterdam, pp 251–257

    Google Scholar 

  19. Mosskov JI, Ettema JS (1977b) Extra-auditory effects in short term exposure to noise from a textile factory. Int Arch Occup Environ Health 40:174–176

    Google Scholar 

  20. Murphy BEP (1967) Some studies of the protein binding of steroids and their application to the routine micro and ultra-micro measurements of various steroids in body fluids by competitive protein binding radioassay. J Clin Endocrinol 27:973–990

    Google Scholar 

  21. Ogle CW, Lockett MF (1966) The release neurohyposeal hormone by sound. J Endocrinol 36:281–290

    Google Scholar 

  22. Ogle CW, Lockett MF (1968) The urinary changes induced in rats by high pitched sounds. J Endocrinol 42:253–260

    Google Scholar 

  23. Ortiz GA, Arguelles AE, Crespin HA, Sposari G, Villafane C (1974) Modifications of epinephrine, nor epinephrine, blood lipid fractions and cardiovascular system produced by noise in an industrial medium. Horm Res 5:57–64

    Google Scholar 

  24. Rahe RH, Robert T, Rubin Arthur RJ, Clark BR (1968) Serum uric acid and cholesterol variability: a comprehensive view of under water demolition team training. J Am Med Assoc 206:2875–2880

    Google Scholar 

  25. Rahe RH, Ryman DH, Biersmer RJ (1976) Serum uric acid, cholesterol and psychological moods throughout stressful naval training. Aviat Space Environ Med 47:883–888

    Google Scholar 

  26. Rai RM, Chaturvedi RC, Singh AP, Malhotra MS (1976) Auditory and non-auditory effects of noise in man. (Abstract) 26th All Indian Annual Conference of Indian Association of Occupational Health, p 19

  27. Singh AP, Rai RM (Unpublished data)

  28. Shatalov NN, Saitanov AO, Glotov KV (1962) On the state of cardiovascular system under conditions involving exposures to the action of permanent noise. Lab Hyg Occup Dis 6: 10–14

    Google Scholar 

  29. Slob A, Wink A, Radder JJ (1973) The effects of acute noise exposure on the excretion of cortico-steroids, adrenalin and nor adrenalin in man. Int Arch Arbeitsmed 31:225–235

    Google Scholar 

  30. Solomon CF (1969) Emotions, stress and central nervous system and immunity. Ann NY Acad 164:335–343

    Google Scholar 

  31. Wootton IDP (1964) Blood lipid, In: Microanalysis in medical biochemistry, 4th edn. J & A Churchill, London, pp 83–86

    Google Scholar 

  32. Yamada A, Jansen MM, Rasmussen AF Jr (1964) Stress and susceptibility to viral infection, III. Antibody response and viral retention during avoidance learning stress. Proc Soc Exp Biol Med 116:677–680

    Google Scholar 

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Authors and Affiliations

  1. Defence Institute of Physiology and Allied Sciences, 110010, Delhi Cantt, India

    R. M. Rai MD, A. P. Singh, T. N. Upadhyay, S. K. B. Patil & H. S. Nayar

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  1. R. M. Rai MD
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  2. A. P. Singh
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  3. T. N. Upadhyay
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  4. S. K. B. Patil
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  5. H. S. Nayar
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Rai, R.M., Singh, A.P., Upadhyay, T.N. et al. Biochemical effects of chronic exposure to noise in man. Int. Arch Occup Environ Heath 48, 331–337 (1981). https://doi.org/10.1007/BF00378681

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  • DOI: https://doi.org/10.1007/BF00378681

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