Summary
Bone density was measured in 28 women with itai-itai disease, 92 men and 114 women with cadmium-induced renal dysfunctions and 44 men and 66 women living in the three different non-polluted areas using a microdensitometer. The values of both indices corresponding to cortical width and bone mineral content were significantly lower in itai-itai disease patients than the cadmium-exposed women with renal dysfunctions and the non-exposed subjects. The cadmium-exposed women also showed a decrease in bone density compared with the non-exposed subjects. A significant decrease in bone density was also observed between cadmium-exposed men and the non-exposed subjects, although the difference was not as clear as in the women. The present study indicates that exposure to cadmium could cause marked osteopenia, particularly in the women.
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Kido, T., Nogawa, K., Yamada, Y. et al. Osteopenia in inhabitants with renal dysfunction induced by exposure to environmental cadmium. Int. Arch Occup Environ Heath 61, 271–276 (1989). https://doi.org/10.1007/BF00381425
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DOI: https://doi.org/10.1007/BF00381425