Summary
A total of 1388 workers employed for at least 3 months at a copper/nickel smelter and nickel refinery were followed up for cancer from 1953 to 1987 through the Finnish Cancer Registry. There were 1339 male and 49 female workers, making a total of 27130 and 706 person-years, respectively. All of the women worked in the refinery, which opened in 1960, the same year the smelting of nickel began. A total of 67 cancers were diagnosed among the men, the standardized incidence ratio for all cancers being 1.0. No cancer was found among the women (1.8 expected). The risk of cancer among men was analysed according to primary site, exposure to nickel, type of work, years since first exposure and age at diagnosis. In the subcohort of nickel refinery workers, one case of sinonasal cancer was observed, against 0.02 expected, but otherwise no significantly increased risks of cancer were found. In addition to the small size of the cohort, the non-positive finding concerning lung cancer might be related to the relatively low arsenic exposure and, perhaps, to the late commencement of nickel production.
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References
Axelson O (1980) Arsenic compounds and cancer. J Toxicol Environ Health 6:1229–1235
Diem K (ed) (1960) Documenta Geigy Wissenschafrliche Tabellen, 6. Auflage. JR Geigy SA, Basel, p 107
Enterline PE, Henderson VL, Marsh GM (1987) Exposure to arsenic and respiratory cancer. A reanalysis. Am J Epidemiol 125:929–938
International Agency for Research on Cancer (1987) Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1–42. (IARC monographs on the evaluation of carcinogenic risks to humans, supplement 7) International Agency for Research on Cancer, Lyon, pp 100–106
International Agency for Research on Cancer (1990) Chromium, nickel and welding. (IARC monographs on the evaluation of carcinogenic risks to humans, vol 49) International Agency for Research on Cancer, Lyon, pp 257–445
International Committee on Nickel Carcinogenesis in Man (1990) Report. Scand J Work Environ Health 16:1–82
Lee-Feldstein A (1986) Cumulative exposure to arsenic and its relationship to respiratory cancer among copper smelter employees. J Occup Med 28:296–302
Pukkala E, Teppo L, Hakulinen T, Rimpelä M (1983) Occupation and smoking as risk determinants of lung cancer. Int J Epidemiol 12:290–296
Saxén E, Teppo L (1978) Finnish Cancer Registry 1952–1977: Twenty-five years of a nationwide cancer registry. Finnish Cancer Registry, Helsinki
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Karjalainen, S., Kerttula, R. & Pukkala, E. Cancer risk among workers at a copper/nickel smelter and nickel refinery in Finland. Int. Arch Occup Environ Heath 63, 547–551 (1992). https://doi.org/10.1007/BF00386344
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DOI: https://doi.org/10.1007/BF00386344