Summary
A total of 60 consecutive patients with localized Ewing's sarcoma of bone who were entered into the Cooperative Ewing's Sarcoma Study of the German Society of Pediatric Oncology from January 1981 until April 1985 were evaluable for tumor volume at diagnosis. The tumor volume was calculated from plain X-rays and CT scans as ellipsoidal or cylindrical depending on the tumor configuration and presence or absence of a soft tissue component. The 3-year disease-free survival rate according to Kaplan-Meier life table analysis was 78% for tumors with a volume <100 ml compared to 17% for tumors ≧100 ml volume. These results were independent of the site of the tumor, though larger tumors were primarily located in central and proximal extremity sites. Maximal tumor extension was less precise than tumor volume in predicting prognosis. The radio of tumor volume to body surface area, body length, or body weight did not increase the ability to separate prognostic groups compared to tumor volume. The better prognosis for patients following radical surgery seems to be in part due to a biased distribution of tumor volumes within local therapy groups, since more patients with smaller tumors had surgery for local control.
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Deméocq F, Carton P, Patte C, Oberlin O, Sarrazin D, Lemerle J (1984) Traitement du sarcome d'Ewing par chimiothérapie initiale intensive. Presse Méd 13:717–721
DeVita VT Jr (1983) The relationship between tumor mass and resistance to chemotherapy. Cancer 51:1209–1220
Gehan AE, Nesbit ME Jr, Burgert EO Jr, Vietti TJ, Tefft M, Perez GA, Kissane J, Hempel C (1981) Prognostic factors in children with Ewing's sarcoma. Natl Cancer Inst Monogr 56:273–278
Glaubiger DL, Robert WM, Schwarz J (1981) Influence of prognostic factors on survival in Ewing's sarcoma. Natl Cancer Inst Monogr 56:285–288
Jürgens H, Csherati M, Göbel U, Gutjahr P, Jobke A, Kaatsch P, Kühl J, Sekera J, Winkler K (1983) Die kooperative Ewing Sarkom Studie CESS 81 der GPO: Zwischenbericht. Klin Pädiat 195:207–213
Kinsella JT, Lichter AS, Miser J, Gerber L, Glatstein E (1984) Local treatment of Ewing's sarcoma: radiation therapy versus surgery. Cancer Treat Rep 68:695–701
Marcus RB, Milton RR (1984) The effect of primary tumor size on the prognosis of Ewing's sarcoma. Int J Radiol Oncol Biol Phys 10 Sup 2:88
Mendenhall CM, Marcus BB Jr, Enneking WF, Springfield DS, Thar TL, Million RR (1983) The prognostic significance of soft tissue extension in Ewing's sarcoma. Cancer 51:913–917
Nesbit ME, Perez CA, Tefft M, Burgert EO Jr, Vietti TJ, Kissane J, Pritchard DJ, Gehan EA (1981) Multimodal therapy for the management of primary, non-metastatic Ewing's sarcoma of bone: an Intergroup Study. Natl Cancer Inst Monogr 56:255–262
Perez CA, Tefft M, Nesbit ME Jr, Burgert EO, Vietti TJ, Kissane J, Pritchard DJ, Gehan AE (1981) Radiation therapy in the multimodal management of Ewing's sarcoma of bone: Report of the Intergroup Ewing's Sarcoma Study. Natl Cancer Inst Monogr 56:263–271
Pomeroy TC, Johnson RE (1975) Combined modality therapy of Ewing's sarcoma. Cancer 35:36–47
Rosen G, Carparros B, Nirenberg A, Marcove RC, Huvos AG, Kosloff C, Lane J, Murphy ML (1981) Ewing's sarcoma: ten-year experience with adjuvant chemotherapy. Cancer 47:2204–2213
Zucker JM, Henry-Amar M, Sarrazin D, Blache R, Platte C, Schweisguth O (1983) Intensive chemotherapy in localized Ewing's sarcoma in childhood. Cancer Cancer 52:415–423
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Dedicated to Professor Dr. G. Schellong on the occasion of his 60th birthday
Supported by „Bundesministerium für Forschung und Technologie (BMFT)”, Grant Number 01 ZP 063 5
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Göbel, V., Jürgens, H., Etspüler, G. et al. Prognostic significance of tumor volume in localized Ewing's sarcoma of bone in children and adolescents. J Cancer Res Clin Oncol 113, 187–191 (1987). https://doi.org/10.1007/BF00391442
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DOI: https://doi.org/10.1007/BF00391442