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The role of interleukin-1 in the pathogenesis of IDDM

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Abbreviations

AA:

Arachidonic acid

AcP:

associated peptide

APC:

antigen presenting cell

BB:

BioBreeding

DAG:

diacylglycerol

FACS:

flourescence activated cell sorter

GTP:

guanosine triphosphate

HLA:

human leukocyte antigen

HSP:

heat shock protein

ICAM:

intercellular adhesion molecule

ICE:

interleukin-1 converting enzyme

iCOX:

inducible cyclooxygenase

IFN:

interferon

IL:

interleukin

IL-1Ra:

IL-1 receptor antagonist

IL-1RT:

IL-1 receptor type

LFA:

lymphocyte function associated

LPS:

lipopolysaccharide

MAPK:

mitogen activated protein kinase

MHC:

major histocompatibility complex

NK:

natural killer

NO:

nitric oxide

NOD:

non-obese diabetic

PARP:

poly(ADP)ribose polymerase

PBMNC:

peripheral blood mononuclear cells

PGE2 :

prostaglandin E2

PHA:

phytohaemagglutinin

PKC:

protein kinase C

PLA:

phospholipase A

PLAP:

phospholipase A activating protein

PLC:

phospholipase C

PPD:

purified protein derivative of tuberculin

scid :

severe combined immunodeficiency

SMnase:

sphingomyelinase

SOD:

Superoxide dismutase

Tc:

T-cytotoxic

Th:

T-helper

TNF:

tumour necrosis factor

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  1. Steno Diabetes Center, 2 Niels Steensens Vej, DK-2820, Gentofte, Denmark

    T. Mandrup-Poulsen

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Presented in part as the Minkowski Lecture, EASD Meeting in Düsseldorf, Germany, September, 1994

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Mandrup-Poulsen, T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39, 1005–1029 (1996). https://doi.org/10.1007/BF00400649

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