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13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers

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Summary

A follow-up was done on the patients of the German multicenter study with severe conglobate acne who had been treated with different dosages of 13-cis-retinoic acid. Eighty-seven patients were monitored from 12 to 21 months. Optimal long-term therapeutic effects were obtained with an initial dose of 1.0 mg/kg body weight, for 3 months, followed by another 3-month-treatment period with 0.2 mg/kg body weight. Six months after the termination of therapy 96% of the patients were still in remission and 81% after 12 months. Comparative figures for the administration of doses were 84% as opposed to 47% (0.5 → 0.2 mg/kg body wt.) and 74% as opposed to 37% (0.2 → 0.2 mg/kg body wt.), respectively. It is suggested from the present data that a high initial dosage of 13-cis-retinoic acid be chosen in order to obtain optimal long-term therapeutic effects. Transiently elevated lipid levels as well as other tolerable side effects return to normal within 3 months at the latest after discontinuation of treatment.

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Authors and Affiliations

  1. Hoffmann-La-Roche AG, Grenzach-Wyhlen, Federal Republic of Germany

    R. Hennes & A. Mack

  2. Department of Dermatology, University of Erlangen, Federal Republic of Germany

    H. Schell

  3. Department of Dermatology, Technical University of Munich, Federal Republic of Germany

    H. J. Vogt

Authors
  1. R. Hennes
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  2. A. Mack
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  3. H. Schell
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  4. H. J. Vogt
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Additional information

Investigators and Departments of Dermatology: City Hospital Augsburg: Beck G, Nikolowski W; University of Berlin, Steglitz: Gollnick H, Orfanos CE; University of Berlin, Rudolf-Virchow: Schweitzer U, Stüttgen G; University of Cologne: Enderer K, Steigleder GK; University of Düsseldorf: Schneider-neuenburg M, Goerz G, Greither A; University of Erlangen: Schell H, Hornstein OP; University of Gießen: Paul E, Illig L; University of Hamburg: Hoting E, Meigel W, Nasemann Th; University of Hannover: Zienau D, Marghescu S; City Hospital Mannheim: Vogt G, Seiler W, Jung EG; City Hospital Munich, Schwabing: Agathos M, Bandmann HJ; University of Munich, L. Maximilian: Plewig G, Braun-Falco O; Technical University of Munich: Vogt HJ, Borelli S; University of Tübingen: Cörlin R, Rassner G

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Hennes, R., Mack, A., Schell, H. et al. 13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers. Arch Dermatol Res 276, 209–215 (1984). https://doi.org/10.1007/BF00414230

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  • DOI: https://doi.org/10.1007/BF00414230

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