Summary
Eight well-trained middle and long distance male runners added to their regular training program a weekly 20-min treadmill run at a velocity calculated to elicit a blood lactate concentration of 4 mmol×1−1. \(\dot V\)O2 max, the running velocity eliciting 4 mmol×1−1 blood lactate (V OBLA), and the activities of citrate synthase (CS), phosphofructokinase (PFK), lactate dehydrogenase (LDH) and LDH isozymes in the M. vastus lateralis were determined before and after 14 weeks of this training. Significant increases were observed in V OBLA and the relative fraction of heart-specific LDH, while the activity of PFK and the ratio of PFK/CS decreased after training. The change in V OBLA was negatively correlated to the mean rate of blood lactate accumulation during the last 15 min of the treadmill training runs, and positively correlated to the percentage of slow twitch fibers in the M. vastus lateralis. The data support the hypothesis that a steady state training intensity which approximates V OBLA will increase V OBLA, and will result in measureable local metabolic adaptations in the active skeletal muscles of well-trained runners without a significant change in maximal aerobic power. Muscle fiber type composition may be an indicator of the “trainability’ of the musculature.
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Bergh U, Thorstensson A, Sjödin B, Hultén B, Piehl K, Karlsson J (1976) Maximal oxygen uptake and muscle fiber types in trained and untrained humans. Med Sci Sports 10: 151–154
Bergström J (1962) Muscle electrolytes in man. Scand J Clin Lab Invest [Suppl] 358
Brooke MH, Kaiser KK (1970) Three “myosin adenosine triphosphatase” systems: the nature of their pH lability and sulfhydryl dependence. J Histochem Cytochem 18: 670–672
Costill DL, Bowers R, Branam G, Sparks K (1971) Muscle glycogen utilization during prolonged exercise on successive days. J Appl Physiol 31: 834–838
Costill DL, Fink WJ, Pollock ML (1976) Muscle fiber composition and enzyme activities of elite distance runners. Med Sci Sports 8: 96–100
Costill DL, Jansson E, Gollnick PD, Saltin B (1974) Glycogen utilization in leg muscle of men during level and uphill running. Acta Physiol Scand 91: 475–481
Costill DL, Sparks K, Gregor R, Turner C (1971) Muscle glycogen utilization during exhaustive running. J Appl Physiol 31: 353–356
Daniels JT, Yarbrough RA, Foster C (1978) Changes in 56-01 max and running performance with training. Eur J Appl Physiol 39: 249–254
Davis JA, Frank MH, Whipp BJ, Wasserman K (1979) Anaerobic threshold alterations caused by endurance training in middle-aged men. J Appl Physiol: Respirat Environ Exerc Physiol 46: 1039–1046
Ekblom B, åstrand PO, Saltin B, Stenberg J, Wallström B (1968) Effect of training on circulatory response to exercise. J Appl Physiol 24: 518–528
Farrell PA, Wilmore J, Coyle E, Billing J, Costill D (1979) Plasma lactate accumulation and distance running performance. Med Sci Sports 11: 338–344
Gollnick PD, Armstrong RB, Saltin B, Saubert CW, Sembrowich WL, Shepherd RE (1973) Effect of training on enzyme activity and fiber composition of human skeletal muscle. J Appl Physiol 34: 107–111
Gollnick PD, Armstrong RB, Saubert CW, Piehl K, Saltin B (1972) Enzyme activity and fiber composition in skeletal muscle of trained and untrained men. J Appl Physiol 33: 312–319
Henriksson J, Reitman JS (1977) Time course of changes in human skeletal muscle succinate dehydrogenase and cytochrome oxidase activities and maximal oxygen uptake with physical activity and inactivity. Acta Physiol Scand 99: 91–97
Hollmann W, Rost R, Liesen H, Dufaux B, Heck H, Mader A (1981) Assessment of different forms of physical activity with respect to preventive and rehabilitative cardiology. Int J Sports Med 2: 67–80
Ivy J, Withers R, Van Handel P, Elger D, Costill D (1980) Muscle respiratory capacity and fiber type as determinants of the lactate threshold. J Appl Physiol: Respirat Environ Exerc Physiol 48: 523–527
Jacobs I (1981) Lactate, muscle glycogen and exercise performance in man. Acta Physiol Scand [Suppl] 495
Karlsson J (1971) Lactate and phosphagen concentrations in working muscle of man. Acta Physiol Scand [Suppl] 358
Karlsson J, Nordesjö L, Jorfeldt L, Saltin B (1972) Muscle lactate, ATP and CP levels during exercise after physical training in man. J Appl Physiol 39: 199–203
Katch V, Weltman A, Sady S, Freedson P (1978) Validity of the relative percent concept for equating training intensity. Eur J Appl Physiol 39: 219–227
Kindermann W, Simon G, Keul J (1979) The significance of the aerobic-anaerobic transition for the determination of work load intensities during endurance training. Eur J Appl Physiol 42: 25–34
Mader A (1980) The contribution of physiology to the science of coaching. In: Zimri U (ed) The art and science of coaching. Netanya, Israel, The Wingate Institute, pp 10–29
Mader A, Liesen H, Heck H, Philippi H, Rost R, Schüren P, Hollman W (1976) Zur Beurteilung der sportartspezifischen AusdauerleistungsfÄhigkeit im Labor. Sportarzt Sportmed 27: 80–88
örlander J, Kiessling KH, Karlsson J, Ekblom B (1977) Low intensity training, inactivity and resumed training in sedentary men. Acta Physiol Scand 101: 351–362
Padykula HA, Herman E (1955) The specificity of the histochemical method for adenosine triphosphatase. J Histochem Cytochem 3: 170–183
Saltin B, Blomqvist G, Mitchell J, Johnson R, Wildenthal K, Chapman C (1968) Response to exercise after bedrest and after training. Circulation 38 [Suppl 5]
Saltin B, Hartley LH, Kilbom å, åstrand I (1969) Physical training in sedentary middle-aged and older men. II. Oxygen uptake, heart rate, and blood lactate concentration at submaximal and maximal exercise. Scand J Clin Lab Invest 24: 323–334
Sjödin B (1976) Lactate dehydrogenase in human skeletal muscle. Acta Physiol Scand [Suppl] 436
Sjödin B, Jacobs I (1981) Onset of blood lactate accumulation and marathon running performance. Int J Sports Med 2: 23–26
Sjödin B, Jacobs I, Karlsson J (1981) Onset of blood lactate accumulation and enzyme activities in M. vastus lateralis in man. Int J Sports Med 2: 166–170
Sjödin B, Thorstensson A, Frith K, Karlsson J (1976) Effect of physical training on LDH activity and LDH isozyme pattern in human skeletal muscle. Acta Physiol Scand 97: 150–157
Skilleter DN, Kun E (1972) The oxidation of l-lactate by liver mitochondria. Arch Biochem Biophys 152: 92–104
Ström G (1949) The influence of anoxia on lactate utilization in man after prolonged muscular work. Acta Physiol Scand 17: 440–451
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Supported in part by grants from the Research Council of the Swedish Sports Federation and the Swedish Armed Forces Enrolment Board
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Sjödin, B., Jacobs, I. & Svedenhag, J. Changes in onset of blood lactate accumulation (OBLA) and muscle enzymes after training at OBLA. Europ. J. Appl. Physiol. 49, 45–57 (1982). https://doi.org/10.1007/BF00428962
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DOI: https://doi.org/10.1007/BF00428962