Abstract
For many years two Danish psychiatric hospitals have used different lithium treatment regimens. In one, slow-release tablets were given in two daily doses and, in the other, conventional tablets were given in a single daily dose. In both hospitals many patients developed polyuria. Multiple regression analyses with sex, age, treatment duration, serum lithium concentration, and treatment regimen as predictor variables showed that the two treatment regimens did not affect the glomerular filtration rate or the proximal reabsorption differently, but that distal water reabsorption was significantly less affected and polyuria less pronounced in the patients given conventional tablets once daily than in those given slow-release tablets twice daily. The authors are divided among themselves as regards the implications of these findings.
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References
Bech P, Vendsborg PB, Rafaelsen OJ (1976) Lithium maintenance treatment of manic-melancholic patients: Its role in the daily routine. Acta Psychiatr Scand 53:70–81
Lauritsen BJ, Mellerup ET, Plenge P, Rasmussen S, Vestergaard P, Schou M (1981) Serum lithium concentrations around the clock with different treatment regimens and the diurnal variation of the renal lithium clearance. Acta Psychiatr Scand 64:314–319
Perry PJ, Dunner FJ, Hahn RL, Tsuang MT, Berg MJ (1981) Lithium kinetics in single daily dosing. Acta Psychiatr Scand 64:281–294
Plenge P, Mellerup ET, Nørgaard T (1981) Functional and structural rat kidney changes by peroral or parenteral lithium treatment. Acta Psychiatr Scand 63:303–313
Plenge P, Mellerup ET, Bolwig TG, Brun C, Hetmar O, Ladefoged J, Larsen S, Rafaelsen OJ (1982) Lithium treatment: Does the kidney prefer one daily dose instead of two? Acta Psychiatr Scand (in press)
Rafaelsen OJ, Bolwig TG, Ladefoged J, Brun C (1979) Kidney function and morphology in long-term lithium treatment. In: Cooper TB, Gershon S, Kline NS, Schou M (eds) Lithium: Controversies and unresolved issues. Excerpta Medica, Amsterdam Oxford Princeton, pp 578–583
Thomsen K, Schou M (1968) Renal lithium excretion in man. Am J Physiol 215:823–827
Thomsen K, Schou M, Steiness I, Hansen HE (1969) Lithium as an indicator of proximal sodium reabsorption. Pflügers Arch 308:180–184
Thomsen K, Olesen OV (1981) Determination of lithium-induced impairment of distal water reabsorption. J Psychiatr Res 16:79–85
Thomsen K, Holstein-Rathlou NH, Leyssac PP (1981) Comparison of three measures of proximal tubular reabsorption: Lithium clearance, occlusion time, and micropuncture. Am J Physiol 241:348–355
Vestergaard P (1980) Sustained-release lithium tablets and renal function. Br Med J 1:113
Vestergaard P, Amdisen A, Hansen HE, Schou M (1979) Lithium treatment and kidney function: A survey of 237 patients in long-term treatment. Acta Psychiatr Scand 62:193–200
Vestergaard P, Amdisen A (1981) Lithium treatment and kidney function: A follow-up study of 237 patients in long-term treatment. Acta Psychiatr Scand 63:333–345
Wallin L, Alling C (1979) Effect of sustained-release lithium tablets on renal function. Br Med J 4:1332
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Schou, M., Amdisen, A., Thomsen, K. et al. Lithium treatment regimen and renal water handling: The significance of dosage pattern and tablet type examined through comparison of results from two clinics with different treatment regimens. Psychopharmacology 77, 387–390 (1982). https://doi.org/10.1007/BF00432777
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DOI: https://doi.org/10.1007/BF00432777