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Non-ossifying fibroma of bone

A histochemical and ultrastructural characterization

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Summary

The microscopic morphology, histochemistry and electron microscopy of a non-ossifying fibroma of the upper metaphysis of the femur in a sixteen-year-old girl, is presented.

The authors describe a fibroblastic cell type as the basis of the neoplasia which transforms itself into a foam cell loaded with lipids. Histochemically it is characterized by high activity in alkaline phosphatases, ATP-ases, fructose 1–6 diphosphatase and NADH-NADPH tetrazolio reductases. Electron microscopy identifies extremely active fibroblastic cells with a synthesis of proteic and lipid material which transforms them into foam cells. The lipids appear irregularly enveloped in laminar systems. There is also a deposit of hemosiderine in certain fibroblasts.

Non-ossifying fibroma differs from the metaphyseal fibrous bone defect as the fibroblasts show a higher activity for alkaline phosphatase and lipids are stored in the cytoplasma.

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Author notes

  1. A. Llombart Bosch (Professor of Pathology)

    Present address: Medical School of Murcia, Spain

Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine and Sanatorio de la Malvarrosa, Valencia, Spain

    A. Llombart Bosch (Professor of Pathology), A. Peydro Olaya & A. Lopez Fernandez

Authors
  1. A. Llombart Bosch
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  2. A. Peydro Olaya
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  3. A. Lopez Fernandez
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Llombart Bosch, A., Peydro Olaya, A. & Lopez Fernandez, A. Non-ossifying fibroma of bone. Virchows Arch. A Path. Anat. and Histol. 362, 13–21 (1974). https://doi.org/10.1007/BF00433771

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  • DOI: https://doi.org/10.1007/BF00433771

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