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Protracted diarrhoea, immunodeficiency and viruses

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Abstract

Protracted diarrhoea (PD) in infancy is a common presenting symptom of severe combined immunodeficiency (SCID), but the pathophysiological mechanisms are usually unexplained. An infant is presented with fatal SCID in whom PD was associated with multiple viral excretion from the intestinal tract and the presence of large PAS-positive macrophages at the villous tips of the jejunum. The possibility of immunodeficiency should be considered in all infants with PD and viruses may play an important role in the pathogenesis of some cases of PD occurring in infants with immunodeficiency.

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Authors and Affiliations

  1. The Hospital for Sick Children, Great Ormond Street, WC1, London, England

    I. W. Booth, I. L. Chrystie, R. J. Levinsky, W. C. Marshall, J. Pincott & J. T. Harries

  2. The Institute of Child Health, 30 Guilford Street, WC1, London, England

    I. W. Booth, I. L. Chrystie, R. J. Levinsky, W. C. Marshall, J. Pincott & J. T. Harries

  3. St. Thomas' Hospital, SE1, London, England, England

    I. W. Booth, I. L. Chrystie, R. J. Levinsky, W. C. Marshall, J. Pincott & J. T. Harries

Authors
  1. I. W. Booth
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  2. I. L. Chrystie
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  3. R. J. Levinsky
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  4. W. C. Marshall
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  5. J. Pincott
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  6. J. T. Harries
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Booth, I.W., Chrystie, I.L., Levinsky, R.J. et al. Protracted diarrhoea, immunodeficiency and viruses. Eur J Pediatr 138, 271–272 (1982). https://doi.org/10.1007/BF00441216

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  • DOI: https://doi.org/10.1007/BF00441216

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