Summary
Guinea pigs were exposed to pure tone noise (2.7 kHz, 130 dB, 1 h) and cochlear microphonic potentials were measured 24 h after exposure.
There is the possibility to modify the resulting noise-induced cochlea damage by regulating the function of the thyroid gland to alter the rate of metabolism. A hypofunction of the thyroid gland during sound exposure lessens, an over-function aggravates the damage.
After gradual adaptation of the animals to a simulated 10,000 m altitude, the electrophysiologically demonstrable noise-induced damage was reduced. This might be explained by the greater hypoxia tolerance and perhaps additional better oxygen supply to the receptor cells.
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Berndt, H., Wagner, H. Influence of thyroid state and improved hypoxia tolerance on noise-induced cochlea damage. Arch Otorhinolaryngol 224, 125–128 (1979). https://doi.org/10.1007/BF00455235
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DOI: https://doi.org/10.1007/BF00455235