Summary
We studied the concentration of neurophysin I ( hNPI) and II (hNPII), the hypothalamo-pituitary carriers of vasopressin and oxytocin, in CSF of depressed and schizophrenic patients and age matched controls. Mean hNPI values were lower and mean hNPII values greater in schizophrenics than in controls. Lower hNPI values were observed in unipolar patients than in controls. In bipolar patients however, higher hNPI values were present. Significantly higher hNPII values were observed in bipolar patients than in controls; no difference was present between unipolars and controls. A positive correlation was observed with age in controls and bipolars for hNPII. These data emphasize the interest of studying the neurohypophysal function in affective illness and in schizophrenia.
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References
Abrams R, Redfield J, Taylor MA (1981) Cognitive dysfunction in schizophrenia, affective disorder and organic brain disease. Br J Psychiatr 139:190–194
Amico Y, Tenicela R, Johnston A, Robinson A (1983) A time dependent peak of oxytocin exists in cerebrospinal fluid but not in plsama of humans. J Clin Endocrinol Metab 57:947–951
Berettini WH, Numberger J, Worthington E, Simmons-Ailing S, Gershon E (1982) Platelet vasopressin receptors in bipolar affective illness. Psychiatry Res 7:83–86
Blake DR, Dodd MJ, Evans JG (1978) Vasopressin in amnesia Lancet I:608
Bohus B, Kovacs GL, De Wied D (1978) Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes. Brain Res 157:414–418
Bondareff W, Mountjoy CQ, Roth M (1981) Selective loss of neurones of origin of adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia. Lancet I:783
Calne ED, Ebert MH, Weingartner H (1977) Cognitive function in primary affective disorder. Neurology 27:1987–1092
Clarke G, Lincoln DW, Merrick L (1979) Dopaminergic control of oxytocin release in lactating rats. J Endocrinol 83:409–420
Courtney N, Raskind M (1983) Vasopressin affects adenylate cyclase activity in rat brain: a possible neuromodulator. Life Sci 19:591–596
De Wied D (1976) Behavioural effects of intraventricularly administered vasopressin and vasopressin fragments. Life Sci 19:685–689
Ettenberg A, van der Kooy D, Le Moal M, Koob GF, Bloom FE (1983) Can aversive properties of (peripherally-injected vasopressin account for its putative role in memory. Behav Brain Res 7:331–350
Ferrier BM, Kennett DJ, Delvin MC (1980) Influences of oxytocin on human memory processes. Life Sci 27:2311–2314
Gjerris A, Fahrenkrug J, Hammer M, Schaffalitzky Del Muckadell DB, Hojholm S, Tendsborg P, Rafaelsen OJ (1980) Peptides in the cerebrospinal fluid of manic melancholic and schizophrenic patients. In: Abstracts 12th CINP Congress, Pergamon Press, London, p 155
Gold PW, Goodwin FK, Reus V (1978) Vasopressin in affective illness. Lancet I:1233–1235
Gold PW, Post RM, Weingartner H, Goodwin FK (1981) Central peptide function in affective illness: Arginine vasopressin as a model system. Adv Biol Psychiatr 7:42–70
Gold PW, Robertson GL, Ballenger J, Goodwin FK, Rubinow D, Kellner D, Post RM (1983) Neurohypophyseal function in affective illness. Psychopharmacol Bull 3:426–431
Hostetter G, Jubb SL, Kozrowski GP (1980) An inability of subcutaneous vasopressin to affect passive avoidance behavior. Neuroendocrinology 30:174–177
Jenkins JS, Mather HM, Conghlan AK, Jenkins DG (1979) Desmopressin in post traumatic amnesia. Lancet 11:1245–1246
Kovacks GL, Bohus B, Versteeg DHG (1979) The effect of vasopressin on memory processes: the role of noradrenergic neurotransmission. Biochem Pharmacol 28:1529–1537
Legros JJ, Louis F (1973) Identification of a vasopressin-neurophysin and of an oxytocin-neurophysin in man. Neuroendocrinology 13:371–375
Legros JJ, Gilot P, Seron X, Claessens J, Adam A, Moeglen JM, Audibert A, Berthier P (1978) Influence of vasopressin on learning and memory. Lancet I:42
Legros JJ, Geenen V, Linkowski P, Mendlewicz J (1983) Increased neurophysin I and II cerebrospinal fluid concentration from bipolar versus unipolar depressed patients. Neuroendocrinol Lett 5:201–205
Pullan PT, Clappison BH, Johnston CI (1979) Plasma vasopressin and human neurophysins in physiological and pathological states associated with changes in vasopressin secretion. J Clin Endocrinol Metab 48:580–587
Raskind VA, Weitzmann RE, Orenstein H, Fisher DA, Courtney N (1978) Is antidiuretic hormone elevated in psychosis. A pilot study. Biol Psychiatr 13:385–387
Reppert JM, Actman HG, Swaminathan F, Fisher DA (1981) Vasopressin exhibits a rhythmic daily pattern in cerebrospinal fluid but not in blood. Science 216:1416–1417
Robinson ICAF, Jones PM (1982) Clearance of neurohypophyseal peptides from cerebrospinal fluid. J Physiol 236:23P
Sahgal A, Keith AB, Wright C, Edwardson JA (1982) Failure of vasopressin to enhance memory in passive avoidance task in rats. Neurosci Lett 28:87–92
Snedecor G, Cochran WG (1967) Statistical methods. 6th edn. The Iowa State University Press, Ames
Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatr 35:273–279
Stetson MA, Watson-Whitmyre B (1976) Nucleus suprachiasmaticus. The biological clock in the hamster Science 191:197–198
Stromgren LS (1977) The influence of depression on memory. Acta Psychiatr Scand 56:109–115
Weingartner A, Gold PW, Ballenger J, Smallberg S, Summers R, Post RM, Goodwin FK (1981) Effects of vasopressin on human memory functions. Science 204:601–603
Whalley LT, Robinson ICAG, Fink G (1982) Oxytocin and neurophysin in post partum mania. Lancet II:387–388
Winer BJ (1972) Statistical principles in experimental design. Mc Graw Hill, New York
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Linkowski, P., Geenen, V., Kerkhofs, M. et al. Cerebrospinal fluid neurophysins in affective illness and in schizophrenia. Eur Arch Psychiatr Neurol Sci 234, 162–165 (1984). https://doi.org/10.1007/BF00461555
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DOI: https://doi.org/10.1007/BF00461555