Zusammenfassung
Die wichtigen Parameter bei der Entwicklung der Thrombose werden bei einem Patienten mit Polyarteriitis nodosa und hochgradiger Innenohrschwerhörigkeit untersucht. Während der akuten Phase bestand eine Hyperaggregation der Thrombozyten, eine verminderte Lebenszeit der Thrombozyten sowie eine verminderte fibrinolytische Aktivität. Möglicherweise sind die beobachteten akustischen und vestibulären Störungen bei diesem Patienten Folge eines thromboembolischen Geschehens im Innenohr.
Summary
Parameters of importance for the development of thrombosis were investigated in a patient with polyarteritis nodosa (PAN) and profound sensorineural hearing loss. During the acute phase, platelet hyperaggregability, shortened platelet survival, and decreased fibrinolytic activity were found. The possibility is discussed that the etiology of the acousticovestibular symptoms in this patient could be an inner ear thromboembolic disorder. It is suggested that platelet functions and fibrinolytic activity should be investigated in patients with acoustico-vestibular symptoms and PAN or other systemic diseases. If abnormalities are found, specific platelet inhibitory and/or fibrinolysis-increasing treatment should be considered as an addition to the conventional medical treatment.
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Bomholt, A., Bjerre Knudsen, J., Permin, H. et al. Profound sensorineural hearing loss in polyarteritis nodosa. Arch Otorhinolaryngol 236, 53–58 (1982). https://doi.org/10.1007/BF00464057
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DOI: https://doi.org/10.1007/BF00464057