Abstract
The capacity of benorylate, an ester of acetylsalicylic acid and paracetamol, to reduce fever in children was compared with that of the components as such or as a combination. The series of cases studied consisted of 66 patients between the ages of 4 months and 12 years with rectal temperatures above 38.5°C. Temperatures were recorded at 15 and 20 min and 1, 2, 4 and 6 hrs after the administration of the drug.
The antipyretic effect of combined acetylsalicylic acid (11 mg/kg) and paracetamol (14 mg/kg) was superior to the effect of benorylate with a dose of 25 mg/kg and even of 50 mg/kg as well as better than the effect of either drug alone.
Acetylsalicylic acid (10 mg/kg) and paracetamol (12.5 mg/kg) alone produced a significantly greater antipyretic effect than benorylate with a dose of 25 mg/kg.
Given in a dose of 35–40 mg/kg, benorylate seems to have a significant antipyretic effect. However, this effect is clearly smaller than that of either of its components, acetylsalicylic acid or paracetamol. Therefore benorylate is probably not suitable to be used as a general antipyretic agent in children.
Similar content being viewed by others
References
Alexander, F., Flahaut, J., Raveschot, H., Drykoningen, G.: A study of the antipyretic activity of a new substance, benorylate in pediatrics. Brux.-méd. 50, 439 (1970)
Beales, D. L., Burry, H. C., Graham, R.: Comparison of aspirin and benorylate in the treatment of rheumatoid disease. Brit. med. J. 1972 II, 483
Colgan, M. T., Mintz, A. A.: The comparative effect of N-acetyl-p-aminophenol and acetylsalicylic acid. J. Pediat. 50, 552 (1957)
Eden, A. N., Kaufman, A.: Clinical comparison of three antipyretic agents. Amer. J. Dis. Child. 114, 284 (1967)
Hunter, J.: Study of antipyretic therapy in current use. Arch. Dis. Childh. 48, 313 (1973)
Kolle, G. von: Zur Behandlung der juvenilen chronischen Polyarthritis und des Still-Syndroms mit einem neuen Antirheumaticum. Z. Rheumaforsch. 30, 227 (1971)
Kouvalainen, K.: Lasten kuumeen hoito. Duodecim (Helsinki) 90, 101 (1974)
Millichap, J. G., Aledort, L. M., Madsen, J. A.: A critical evaluation of therapy of febrile seizures. J. Pediat. 56, 364 (1960)
Powell, R. H., Ansell, B. M.: Benorylate in management of Still's disease. Brit. med. J. 1974 I, 145
Robertson, A.: Benorylate absorption and metabolism. Abstracts of papers in 8th Europ. Rheum. Conference (1971)
Robertson, A., Glynn, J. P., Watson, A. K.: The absorption and metabolism in man of 4-(acetamido)phenyl-2-acetoxybenzoate (Benorylate). Xenobiotica 2, 339 (1972)
Rosner, I., Malhie, P., Mottot, G.: Pharmacologie du 4-(acétamido) phenyl-2-acétoxybenzoate (Win 11450). Thérapie 23, 525 (1968)
Steele, R. W., Young, F. S. H., Bass, J. W., Shirkey, H. C.: Oral antipyretic therapy. Evaluation of aspirin-acetaminophen combination. Amer. J. Dis. Child. 123, 204 (1972)
Weill, J., Gaillon, R., Renon, C., Lejeune, C.: A new antipyretic for pediatric usage, 4-(acetamido) phenyl-2-acetoxybenzoate. Thérapie 23, 541 (1968)
Vest, M., Olafsson, A., Girard, J.: Die antipyretische Wirkung von Benorylate, 4-(Acetamido) phenyl-2-acetoxybenzoat, im Vergleich mit Aspirin und Alcaxyl bei Kindern. Ther. Umsch. 28, 625 (1971)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Similä, S., Keinänen, S. & Kouvalainen, K. Oral antipyretic therapy. Eur J Pediatr 121, 15–20 (1975). https://doi.org/10.1007/BF00464391
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00464391