Summary
The effects of slow-release furosemide and bendroflumethiazide in the ambulatory treatment of mild to moderate congestive heart failure were compared in a controlled multicentre study using a randomized, double-blind procedure. In the first trial, slow-release furosemide 60 mg daily was compared with 2.5 mg bendroflumethiazide; in the second trial the daily doses were 30 mg and 2.5 mg, respectively. There were 47 patients in Trial I and 39 in Trial II. The randomised allocation to the treatment regimen was made after a four-week period on bendroflumethiazide 2.5 mg daily, and treatment was continued for 12 weeks. Clinical and laboratory data were recorded before, during and at the end of the trial. Adverse effects were few and minor in both medication groups, and there were no significant intergroup differences. It was concluded slow-release furosemide 30 mg or 60 mg daily was as effective as bendroflumethiazide 2.5 mg daily for maintenance treatment in mild to moderate congestive heart failure.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hutcheon D, Nemeth E, Quinlan D (1980) The role of furosemide alone and in combination with digoxin in the relief of symptoms of congestive heart failure. J Clin Pharmacol 20: 59–68
The Criteria Committee of the New York Heart Association (1964) Diseases of the heart and blood vessels (nomenclature and criteria for diagnosis) 6th edn. Little, Brown, Boston
Pothuizen LM, Chadha DR (1982) Treatment of congestive cardiac failure in elderly patients: randomized study of hydrochlorothiazide and slow-release furosemide. Curr Ther Res 32: 513–519
Vermeulen A, Chadha DR (1982) Slow-release furosemide and hydrochlorothiazide in congestive cardiac failure: a controlled trial. J Clin Pharmacol 22: 513–519
Finnerty FA, Maxwell MH, Lunn J, Moser M (1977) Long-term effects of furosemide and hydroclorothiazide in patients with essential hypertension. Angiology 28: 125–133
Araoye MA, Chang MY, Khatri IM, Freis ED (1978) Furosemide compared to hydrochlorothiazide. Long-term treatment in hypertension. Am Med Assoc 240: 1863–1866
Humphreys DM (1966) Acute gout apparently precipitated by furosemide. Br Med J 1: 1024–1025
Shapiro AP, Banedek TG, Small JL (1961) Effect of thiazide on carbohydrate metabolism in patients with hypertension. N Engl J Med 265: 1028–1033
Brown WJ, Brown FK (1967) Thiazide-induced alteration of carbohydrate tolerance in normal men. Curr Ther Res 9: 200–207
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pehrsson, S.K. Multicentre comparison between slow-release furosemide and bendroflumethiazide in congestive heart failure. Eur J Clin Pharmacol 28, 235–239 (1985). https://doi.org/10.1007/BF00543315
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00543315