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Information on drug use in pregnancy from the viewpoint regional drug information centre

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Summary

The need for information on drug use during pregnancy was assessed by reviewing the requests for information arriving at a drug information centre in the past nine years. Of all the queries received 24% concerned this aspect, of which the majority were focused on drug use during pregnancy. Mothers received an average of 2.6 prescriptions, most frequently for antiinfectives, psychotropics, hormones and non-narcotic analgesics. Questions were answered personally after a literature search. A profile of questions and a summary of model cases registered in the archives of the centre are reported.

The evaluation confirmed the need for and value of a drug information service in relation to pregnancy, so as to avoid alarmist and falsely reassuring attitudes in a field where knowledge is often based on scanty information.

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References

  1. Boethius G (1977) Recording of drug prescriptions in the county of Jamtland, Sweden. II. Drug exposure of pregnant women in relation to course and outcome of pregnancy. Eur J Clin Pharmacol 12: 37–43

    Google Scholar 

  2. Heinonen OP, Slone D, Shapiro S (1977) Birth defects and drugs in pregnancy. Publishing Sciences Group, Littleton

    Google Scholar 

  3. Brocklebank JC, Ray WA, Federspiel CF, Schaffner W (1978) Drug prescribing during pregnancy. A controlled study of Tennessee Medicaid recipients. Am J Obstet Gynecol 132: 235–244

    Google Scholar 

  4. Doering PL, Stewart RB (1978) The extent and character of drug consumption during pregnancy. J Am Med Assoc 239: 843–846

    Google Scholar 

  5. Bodendorfer TW, Briggs GG, Gunning JE (1979) Obtaining drug exposure histories during pregnancy. Am J Obstet Gynecol 135: 490–494

    Google Scholar 

  6. Rubin PC, Craig GF, Gavin K, Sumner D (1986) Prospective survey of use of therapeutic drugs, alcohol, and cigarettes during pregnancy. Br Med J [Clin Res] 292: 81–83

    Google Scholar 

  7. Rubin PC (1986) General principles. Br Med J [Clin Res] 293: 1415–1417

    Google Scholar 

  8. Robboy SJ, Noller KL, O'Brien P, Kaufman RH, Townsend D, Barnes AB, Gundersen J, Lawrence D, Bergstrahl E, McGorray S, Tilley BC, Anton J, Chazen G (1984) Increased incidence of cervical and vaginal dysplasia in 3980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project. J Am Med Assoc 252: 2979–2983

    Google Scholar 

  9. Greenberg ER, Barnes AB, Resseguie L, Barrett JA, Burnside S, Lanza LL, Neff RK, Stevens M, Young RH, Colton T (1984) Breast cancer in mothers given diethylstilbestrol in pregnancy. N Engl J Med 311: 1393–1398

    Google Scholar 

  10. L'E Orme M (1985) The Debendox saga. Br Med J [lin Res] 291: 918–919

    Google Scholar 

  11. Gal P, Sharpless MK (1984) Fetal drug exposure-behavioral teratogenesis. Drug Intell Clin Pharm 18: 186–201

    Google Scholar 

  12. World Health Organization, Regional Office for Europe, Copenhagen (1987) Guidelines for the assessment of drugs and other chemicals for behavioural teratogenicity. WHO, Regional Office for Europe, Copenhagen

    Google Scholar 

  13. Davies DM, Ashron CH, Rao JG, Rawlins MD, Routledge PA, Savage RL, Thompson JW, Zar MA (1977) Comprehensive clinical drug information service: First year's experience. Br Med J [Clin Res] 1: 89–90

    Google Scholar 

  14. Editorial (1978) Getting information we need-how drug information centres can help. Drug Ther Bull 16: 41–44

  15. Alvan G, Ohman B, Sjöqvist F (1983) Problem-oriented drug information: A clinical pharmacological service. Lancet 2: 1410–1412

    Google Scholar 

  16. Bonati M, Tognoni G (1984) Has clinical pharmacology lost its way? Lancet 1: 556–558

    Google Scholar 

  17. Tognoni G, Bonati M (1986) Second-generation clinical pharmacology. Lancet 1: 1028–1029

    Google Scholar 

  18. Arnold RM, Nissen JC, Campbell NA (1987) Ethical issues in a drug information center. Drug Intell Clin Pharm 21: 1008–1011

    Google Scholar 

  19. Rutstein DD, Berenberg W, Chalmers TC, Child CG 3rd Fishman AP, Perrin EB (1976) Measuring the quality of medical care. A clinical method. N Engl J Med 294: 582–588

    Google Scholar 

  20. Piper JM, Baum C, Kennedy DL (1987) Prescription drug use before and during pregnancy in a Medicaid population. Am J Obstet Gynecol 157: 148–156

    Google Scholar 

  21. Safra MJ, Oakley GP Jr (1975) Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. Lancet 2: 478–480

    Google Scholar 

  22. Saxen I, Saxen L (1975) Association between maternal intake of diazepam and oral clefts. Lancet 2: 498

    Google Scholar 

  23. Committee on Drugs. American Academy of Pediatrics (1982) Psychotropic drugs in pregnancy and lactation. Pediatrics 69: 241–243

    Google Scholar 

  24. Rosenberg L, Mitchell AA, Parsells JL, Pashayan H, Louik C, Shapiro S (1983) Lack of relation of oral clefts to diazepam use during pregnancy. N Engl J Med 309: 1282–1285

    Google Scholar 

  25. Robinson GE, Stewart DE, Flak E (1986) The rational use of psychotropic drugs in pregnancy and postpartum. Can J Psychiatry 31: 183–190

    Google Scholar 

  26. Laegreid L, Olegard R, Wahlstrom J, Conradi N (1987) Abnormalities in children exposed to benzodiazepines in utero. Lancet 1: 108–109

    Google Scholar 

  27. Rayburn WF, Lavin JP Jr (1986) Drug prescribing for chronic medical disorders during pregnancy: An overview. Am J Obstet Gynecol 155: 565–569

    Google Scholar 

  28. Chaplin S, Sanders GL, Smith JM (1982) Drug excretion in human breast milk. Adverse Drug React Acute Poisoning Rev 1: 225–287

    Google Scholar 

  29. Committee on Drugs. American Academy of Pediatrics (1983) The transfer of drugs and other chemicals into human breast milk. Pediatrics 72: 375–383

    Google Scholar 

  30. Hawkins DF, ed (1983) Drugs and pregnancy. Human teratogenesis related problems. Churchill Livingstone, Edinburgh

    Google Scholar 

  31. Editorial (1983) Drugs which can be given to nursing mothers. Drug Ther Bull 21: 5–8

  32. Briggs GG, Freeman RK, Yaffe SJ (1986) Drugs in pregnancy and lactation (2nd. edn) Williams & Wilkins, Baltimore

    Google Scholar 

  33. Rayburn WF, Zuspan FP, eds (1986) Drug therapy in obstetrics and gynecology (2nd. edn) Appleton Century Crofts, Norwalk, Connecticut

    Google Scholar 

  34. Matheson I, Kristensen K, Lunde PKM (1986) Breast-feeding, maternal and infant drug use postpartum. Acta Pharmacol Toxicol 59 [Suppl V]: A 516

  35. Heymann MA (1986) Non-narcotic analgesics use in pregnancy and fetal and perinatal effects. Drugs 32 [Suppl 4]: 164–176

    Google Scholar 

  36. Loudon JB (1987) Psychotropic drugs. Br Med J [Clin Res] 294: 167–169

    Google Scholar 

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Author notes

  1. O. Kasilo

    Present address: Department of Pharmacy, Drugs and Toxicology Information Service, Godfrey Huggins School of Medicine, P.O. Box A 178, Avondale, Harare, Zimbabwe

Authors and Affiliations

  1. Laboratory of Clinical Pharmacology, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy

    O. Kasilo, M. Romero, M. Bonati & G. Tognoni

Authors
  1. O. Kasilo
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  2. M. Romero
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  3. M. Bonati
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  4. G. Tognoni
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Kasilo, O., Romero, M., Bonati, M. et al. Information on drug use in pregnancy from the viewpoint regional drug information centre. Eur J Clin Pharmacol 35, 447–453 (1988). https://doi.org/10.1007/BF00558237

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  • DOI: https://doi.org/10.1007/BF00558237

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