Summary
The absorption of paracetamol from syrup, tablet and two different suppository bases was compared in six adult volunteers using urinary excretion measurements. The total amount of paracetamol and its metabolites excreted and the peak excretion rates were lower from the suppository bases than from the oral dosage forms. Absorption was a little better from a polyethylene glycol suppository base than from a triglyceride base. The antipyretic efficacy of a paracetamol syrup and suppository at a dose of 10 mg/kg was compared in 30 children between the age of 4 months and 12 years, who had infections and a rectal temperature above 38.5°C. Both dosage forms produced a significant decrease in temperature, the greatest fall being about 2 hours earlier with the oral dosage form. The syrup also seemed to be significantly (p<0.05) more effective (maximum fall of temperature 1.58°C) in reducing fever than the suppository, which produced its greatest fall of temperature (1.24°C) six hours after insertion of the suppository. From the practical point of view both forms can be regarded as safe and effective antipyretics.
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References
Colgan, M.T., Mintz, A.A.: The comparative antipyretic effect of N-acetyl-p-aminophenol and acetylsalicylic acid. J. Pediatr.50, 552–5 (1957)
Coulding, Roy: Acetaminophen poisoning. Pediatrics52, 883–4 (1973)
Eden, A.N., Kaufman, A.: Clinical comparison of three antipyretic agents. Amer. J. Dis. Child.144, 284–7 (1967)
Feldman, S.: Biovailability of acetaminophen suppositories. Amer. J. Hosp. Pharm.32, 1173–5 (1975)
Hunter, J.: Study of antipyretic therapy in current use. Arch. Dis. Child48, 313–5 (1973)
Moës, A., Jaminet, F.: Influence of aging of suppositories on rectal absorption of paracetamol. Acta helv. Pharm.51, 119–25 (1976)
Mrochek, J.E., Katz, S., Christie, W.H., Dinsmore, S.R.: Acetaminophen metabolism in man, as determined by high-resolution liquid chromatography. Clin. Chem.20, 1086–96 (1974)
Nowak, M.M., Grundhofer, B., Gibaldi, M.: Rectal absorption from aspirin suppositories in children and adults. Pediatrics54, 23–6 (1974)
Pagay, S.N., Poust, R.I., Colaizzi, J.L.: Influence of vehicle dielectric properties on acetaminophen bioavailability from polyethylene glycol suppositories. J. Pharm. Sci.63, 44–7 (1974)
Parrot, E.L.: Salicylate absorption from suppositories. J. Pharm. Sci.60, 867–72 (1971)
Shangraw, R.F., Walking, W.D.: Effect of vehicle dielectric properties on rectal absorption of acetaminophen. J. Pharm. Sci.60, 600–2 (1971)
Similä, S., Kouvalainen, K., Keinänen, S.: Oral antipyretic therapy. Evaluation of ibuprofen. Scand. J. Rheumatol.5, 81–3 (1976)
Wagner, J.G., Carter, C.H., Martens, J.J.: Serum concentrations after rectal administration of lincomycin hydrochloride. J. clin. Pharmacol.8, 154–63 (1968)
Welch, R.M., Conney, A.H.: A simple method for the quantitative determination of N-acetyl-p-aminophenol (APAP) in urine. Clin. Chem.11, 1064–7 (1965)
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Keinänen, S., Hietula, M., Similä, S. et al. Antipyretic therapy. Eur J Clin Pharmacol 12, 77–80 (1977). https://doi.org/10.1007/BF00561410
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DOI: https://doi.org/10.1007/BF00561410