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Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus

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Abstract

A total of 1419 children with type 1 diabetes mellitus was investigated in order to assess the true frequency of Hashimoto's thyroiditis (HT), diagnosed by microsomal and/or thyroglobulin autoantibodies, by ultrasound and in many cases also by fine needle biopsy. According to these criteria, 55 cases (3.9%) of HT were identified, a number significantly higher (P<0.0001) than the distribution reported in the normal paediatric population. No typical antibody pattern was seen prior to the onset of HT, nor was an antibody threshold level found which could have been diagnostic for this disease. Patients with subclinical hypothyroidism were treated withl-thyroxine and were investigated regarding the behaviour of anti-thyroid autoantibodies; however, no significant changes were seen. The data showed a high frequency of HT in diabetic children, and therefore we recommend that children with type 1 diabetes mellitus should be screened for thyroid autoantibodies and those positive should undergo periodic thyroid function testing.

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References

  1. Betterle C, Zanette F, Pedini B, Presotto F, Rapp LB, Monciotti CM, Rigon F, Clinical and subclinical organ-specific autoimmune manifestations in type 1 (insulin-dependent) diabetic patients and their first-degree relatives. Diabetologia 26:431–436, 1984

    Google Scholar 

  2. Gilani BB, MacGillivray MH, Voorhess ML, Mills BJ, Riley RJ, MacLaren NK, Thyroid hormone abnormalities at diagnosis of insulin-dependent diabetes mellitus in children. J Pediatr 105: 218–222, 1984

    Google Scholar 

  3. Pavia Sesma C, Valls Tolosa C, Eighian Baho B, Gallart Marsillas M, Albarran Deogracias JM, Thyroid autoimmunity in type 1 (insulin-dependent) diabetes mellitus. An Esp Pediatr 31: 523–527, 1989

    Google Scholar 

  4. Doniach D, Bottazzo GF, Khoury EL, Prospects in human autoimmune thyroiditis. In: Pinchera A, Doniach D, Fenzi GF, Baschieri L (eds) Autoimmune aspects of endocrine disorders. Academic Press, London, pp 25–38, 1980

    Google Scholar 

  5. Rallison ML, Dobyns DM, Keating FR, Rall JE, Tyler FH, Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr 86:675–682, 1975

    Google Scholar 

  6. Hashizume K, DeGroot LJ, Release of thyrotropin receptor from thyroid plasma membranes: effect of hydrocortisone, propanolol and adenosine 3′,5′-monophosphate. Endocrinology 106: 1463–1468, 1980

    Google Scholar 

  7. Nystrom E, Lundberg PA, Lindsted G, Rebound increase in serum thyrotropin, anti-microsomal antibodies and thyroglobulin after discontinuation ofl-thyroxine. J Intern Med 228:497–501, 1990

    Google Scholar 

  8. Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T, Test for recovery from hypothyroidism during thyroxine therapy in Hashimoto's thyroiditis. Lancet 336:1084–1086, 1990

    Google Scholar 

  9. Rivkees SA, Bode HH, Crawford JD, Long-term growth in juvenile acquired hypothyroidism: the failure to achieve normal adult stature. N Engl J Med 318:599–602, 1988

    Google Scholar 

  10. Valdermarsson S, Hansson P, Hedner P, Nilsson-Ehle P, Relationship between thyroid function, hepatic lipoprotein lipase activities, and plasma lipoprotein concentrations. Acta Endocrinol 104:50–56, 1983

    Google Scholar 

  11. Bastenie PA, Vanhaelst L, Goldstein J, Smets PH, Asymptomatic autoimmune thyroiditis and coronary heart disease. Cross sectional and prospective study. Lancet 2:155–158, 1977

    Google Scholar 

  12. Tieche M, Lupi GA, Gutzwiller F, Grob PJ, Studer H, Burgi H, Borderline thyroid function and thyroid autoimmunity. Risk factors for coronary heart disease? Br Heart J 46:202–206, 1981

    Google Scholar 

  13. Kannel WB, Lipids, diabetes, and coronary heart disease: insights from the Framingham Study. Am Heart J 110:1100–1107, 1985

    Google Scholar 

  14. Krolewski AS, Kosinski EJ, Warram JH, Leland OS, Busick EJ, Asmal AC, Rand LI, Christlieb AR, Bradley RF, Kahn CR, Magnitude and determinants of coronary artery disease in juvenileonset, insulin-dependent diabetes mellitus. Am J Cardiol 59: 750–755, 1987

    Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, General Hospital of Bolzano, Via Lorenz Boehler 5, I-39100, Bolzano, Italy

    G. Radetti, C. Paganini & L. Gentili

  2. Department of Paediatrics, University of Parma, Italy

    S. Bernasconi

  3. Institute of Semeiotica Medica, University of Padua, Italy

    C. Betterle

  4. Department of Paediatrics, University of Graz, Austria

    M. Borkenstein

  5. Department of Paediatrics, University of Rijeka, Croatia

    K. Cvijovic

  6. Department of Paediatrics, University of Zagreb, Croatia

    M. Kadrnka-Lovrencic

  7. Department of Paediatrics, University of Ljubljana, Slovenia

    C. Krzisnik & T. Battelino

  8. Department of Paediatrics, University of Pavia, Italy

    R. Lorini

  9. Department of Paediatrics, University of Trieste, Italy

    S. Marinoni & G. Tonini

  10. Department of Paediatrics, University of Padua, Italy

    F. Rigon

  11. Department of Paediatrics, University of Verona, Italy

    L. Tatò & L. Pinelli

Authors
  1. G. Radetti
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  2. C. Paganini
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  3. L. Gentili
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  4. S. Bernasconi
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  5. C. Betterle
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  6. M. Borkenstein
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  7. K. Cvijovic
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  8. M. Kadrnka-Lovrencic
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  9. C. Krzisnik
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  10. T. Battelino
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  11. R. Lorini
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  12. S. Marinoni
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  13. F. Rigon
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  14. L. Tatò
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  15. L. Pinelli
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  16. G. Tonini
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Additional information

A collaborative study of the AASGPED-Alpe Adria Study Group of Pediatric Endocrinology and Diabetology

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Radetti, G., Paganini, C., Gentili, L. et al. Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus. Acta Diabetol 32, 121–124 (1995). https://doi.org/10.1007/BF00569570

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  • DOI: https://doi.org/10.1007/BF00569570

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