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Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects

I. Uric acid kinetics

  • Clinical Pharmacology
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Abstract

The interaction of allopurinol (300 mg/day) and hydrochlorothiazide (50 mg/day) was studied in seven healthy male volunteers during prolonged coadministration of the two drugs using defined dietary conditions. A formula diet was administered with the allopurinol throughout the 24-day study, while hydrochlorothiazide was added during days 11–21. After the addition of hydrochlorothiazide both plasma uric acid and plasma oxipurinol rose for 6 days – 24% and 30%, respectively, compared to steady-state levels during allopurinol alone (P < 0.01 each). In neither substance were variations in renal excretion significant. By the end of combined treatment (day 21), the changes induced by hydrochlorothiazide had already been reversed to a considerable extent. It is concluded that both in normal individuals and in patients with normal renal clearance of uric acid the effect of hydrochlorothiazide on the plasma concentration and renal excretion of oxipurinol is small. When taking both drugs, there is no increased risk during long-term treatment, and a risk is even questionable during the first days.

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Abbreviations

Oxi:

Oxipurinol

UA:

uric acid

Allo:

allopurinol

HCT:

hydrochlorothiazide

AHS:

allopurinol hypersensitivity syndrome

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Authors and Affiliations

  1. Medizinische Poliklinik, Universität München, Pettenkoferstrasse 8a, D-80336, München, Germany

    W. Löffler, R. Landthaler & N. Zöllner

  2. Abteilung Klinische Pharmakologie, Medizinische Klinik, Universität Heidelberg, Bergheimerstrasse 58, D-69115, Heidelberg, Germany

    J. X. de Vries, I. Walter-Sack, A. Ittensohn & A. Voss

Authors
  1. W. Löffler
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  2. R. Landthaler
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  3. J. X. de Vries
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  4. I. Walter-Sack
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  5. A. Ittensohn
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  6. A. Voss
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  7. N. Zöllner
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Part of this work will be included in the dissertation of Mr. R. Landthaler, Medizinische Fakultät der Universität München

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Löffler, W., Landthaler, R., de Vries, J.X. et al. Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects. Clin Investig 72, 1071–1075 (1994). https://doi.org/10.1007/BF00577758

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  • DOI: https://doi.org/10.1007/BF00577758

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