Abstract
The origin of nitric oxide synthase-containing nerve fibers in rat celiac-superior mesenteric ganglion was examined using retrograde tracing techniques combined with the immunofluorescence method. Fluoro-Gold was injected into the celiac-superior mesenteric ganglion. Neuronal cell bodies retrogradely labeled with Fluoro-Gold in the thoracic spinal cord, the dorsal root ganglia at the thoracic level, the nodose ganglion, and the intestine from the duodenum to the proximal colon were examined for nitric oxide synthase immunoreactivity. About 60% of sympathetic preganglionic neurons in the intermediolateral nucleus projecting to the celiac-superior mesenteric ganglion were immunoreactive for nitric oxide synthase, as were approximately 27% of nodose ganglion neurons and about 65% of dorsal root ganglion neurons projecting to the cceliac-superior mesenteric ganglion. Neurons projecting to the celiac-superior mesenteric ganglion were found in the myenteric plexus of the small and large intestine. In the proximal colon, about 23% of such neurons were immunoreactive for nitric oxide synthase. However, in the small intestine, no immunoreactivity was found in these neurons.
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References
Aimi Y, Fujimura M, Vincent SR, Kimura H (1991) Localization of NADPH-diaphorase-containing neurons in sensory ganglia of the rat. J Comp Neurol 306:382–392
Anderson CR (1992) NADPH diaphorase-positive neurons in the rat spinal cord include a subpopulation of autonomic preganglionic neurons. Neurosci Lett 139:280–284
Anderson CR, McLachlan EM, Srb-Christie O (1989) Distribution of sympathetic preganglionic neurons and monoaminergic nerve terminals in the spinal cord of the rat. J Comp Neurol 283:269–284
Anderson CR, Edwards SL, Furness JB, Bredt DS, Snyder SH (1993) The distribution of nitric oxide synthase-containing autonomic preganglionic terminals in the rat. Brain Res 614:78–85
Berthoud H-R, Powley TL (1993) Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia. J Auton Nerv Syst 42:153–170
Blottner D, Baumgarten H-G (1992) Nitric oxide synthetase (NOS)-containing sympathoadrenal cholinergic neurons of the rat IML-cell column: evidence from histochemistry, immunohistochemistry, and retrograde labeling. J Comp Neurol 316:45–55
Blottner D, Schmidt HHHW, Baumgarten HG (1993) Nitroxergic autonomic neurones in rat spinal cord. Neuroreport 4:923–926
Briggs CA (1992) Potentiation of nicotinic transmission in the rat superior cervical sympathetic ganglion: effects of cyclic GMP and nitric oxide generators. Brain Res 573:139–146
Costa M, Furness JB, Pompolo S, Brookes SJH Bornstein JC, Bredt DS, Snyder SH (1992) Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine. Neurosci Lett 148:121–125
Domoto T, Yang H, Bishop AE, Polak JM, Oki M (1992) Distribution and origin of extrinsic nerve fibers containing calcitonin gene-related peptide, substance P and galanin in the rat upper rectum. Neurosci Res 15:64–73
Furness JB, Anderson CR (1993) Origins of nerve terminals containing nitric oxide synthase in the guinea-pig coeliac ganglion. J Auton Nerv Syst 46:47–54
Kuramoto H, Furness JB (1989) Distribution of enteric nerve cells that project from the small intestine to the coeliac ganglion in the guinea-pig. J Auton nerv Syst 27:241–248
Lindh B, Hökfelt T, Elfvin L-G (1988) Distribution and origin of peptide-containing nerve fibers in the celiac superior mesenteric ganglion of the guinea-pig. Neuroscience 26:1037–1071
McConalogue K, Furness JB (1993) Projections of nitric oxide synthesizing neurons in the guinea-pig colon. Cell Tissue Res 271:545–553
Messenger JP, Furness JB (1993) Distribution of enteric nerve cells projecting to the superior and inferior mesenteric ganglia of the guinea-pig. Cell Tissue Res 271:333–339
Petras JM, Cummings JF (1972) Autonomic neurons in the spinal cord of the rhesus monkey: a correlation of the findings of cytoarchitectonics and sympathectomy with fiber degeneration following dorsal rhizotomy. J Comp Neurol 146:189–218
Santer RM, Symons D (1993) Distribution of NADPH-diaphorase activity in rat paravertebral, prevertebral and pelvic sympathetic ganglia. Cell Tissue Res 271:115–121
Sheng H, Hughes ML, Murad F, Briggs CA (1992) Evidence that nitric oxide mediates the cyclic GMP response to synaptic activity in the rat superior cervical ganglion. Brain Res 597:343–345
Springall DR, Riveros-Moreno V, Buttery L, Suburo A, Bishop AE, Merrett M, Moncada S, Polak JM (1992) Immunological detection of nitric oxide synthase(s) in human tissues using heterologus antibodies suggesting different isoforms. Histochemistry 98:259–266
Strack AM, Sawyer, WB Marubio LM, Loewy AD (1988) Spinal origin of sympathetic preganglionic neurons in the rat. Brain Res 455:187–191
Vizzard MA, Erdman SL, Groat WC de (1993) Localization of NADPH-diaphorase in pelvic afferent and efferent pathways of the rat. Neurosci Lett 152:72–76
Vizzard MA, Erdman SL, Roppolo JR, Förstermann U, Groat WC de (1994) Differential localization of neuronal nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in the rat spinal cord. Cell Tissue Res 278:299–309
Young HM, Furness JB, Shuttleworth CWR, Bredt DS, Snyder SH (1992) Co-localization of nitric oxide synthase immunoreactivity and NADPH diaphorase staining in neurons of the guinea-pig intestine. Histochemistry 97:375–378
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Domoto, T., Teramoto, M., Tanigawa, K. et al. Origins of nerve fibers containing nitric oxide synthase in the rat celiac-superior mesenteric ganglion. Cell Tissue Res. 281, 215–221 (1995). https://doi.org/10.1007/BF00583390
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DOI: https://doi.org/10.1007/BF00583390