Summary
Intracoronary blood volume in relation to coronary perfusion pressure was estimated in dog hearts in situ with cannulated left coronary arteries. Electromagnetically measured inflow into coronary arteries times mean transit time, obtained by a dye dilution technique determined the intracoronary blood volume. Within the range from 70 and 170 mm Hg coronary perfusion pressure the mean value of intracoronary blood volume increases from 11.0 to 17.8 ml per 100 g wet weight; an increase of about 62%. The mycocardial wall at 70 mm Hg consists of 10.4% intracoronary blood and at 170 mm Hg of 15.1%. A significant increase in intracoronary blood volume is seen with increasing coronary perfusion pressure at constant coronary flow.
With increasing coronary perfusion pressure the outer volume of the heart and the volume of the myocardial wall increases while the inner volume of the left ventricle decreases in blood perfused dog hearts in situ and in isolated cat hearts. The mean radius of the left ventricle is not changed by the coronary perfusion pressure. This change in the geometry of the left ventricle influences the pressurevolume relation of the heart and can explain the effect of coronary perfusion pressure on the performance of the heart.
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Morgenstern, C., Höljes, U., Arnold, G. et al. The influence of coronary pressure and coronary flow on intracoronary blood volume and geometry of the left ventricle. Pflugers Arch. 340, 101–111 (1973). https://doi.org/10.1007/BF00588169
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DOI: https://doi.org/10.1007/BF00588169