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Hypophysäre Gonadotropine und ovarielle Steroide im Serum während des normalen menstruellen Cyclus und bei Corpus-luteum-Insuffizienz

LH, FSH and ovarian steroids in serum during normal menstrual cycles and cycles with corpus luteum insufficiency in the human female

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Summary

LH, FSH, estradiol-17β, progesterone, 20α-dihydroprogesterone, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone are determined by radioimmunoassay in serum daily during 11 menstrual cycles. Three of them had to be considered as cycles with corpus luteum insufficiency on the basis of basal body temperature, length of the luteal phase and the pattern of progesterone concentration in serum. One woman conceived during the investigated cycle.

The present concepts of the regulation of ovulation are discussed on the basis of the chronological relationship of changing endocrine parameters in serum during the cycles. The analysis of the hormone concentrations in serum during the cycles with corpus luteum insufficiency supports the view that corpus luteum insufficiency could be caused by an insufficient stimulation of the growing follicle, but other etiological factors have also to be considered.

Zusammenfassung

LH, FSH, Östradiol-17β, Progesteron, 20α-Dihydroprogesteron, 17α-Hydroxyprogesteron, Δ4-Androstendion und Testosteron wurden während 11 menstrueller Cyclen täglich im Serum radioimmunologisch bestimmt. Von den 11 untersuchten Cyclen stellten sich 8 nach Beurteilung von Basaltemperatur, Dauer der Sekretionsphase und Progesteronkonzentration im Serum als wahrscheinlich normal heraus, während 3 Cyclen die Zeichen einer Corpus-luteum-Insuffizienz unterschiedlicher Ausprägung boten. Während eines der 8 normalen Cyclen kam es zur Konzeption. Heute existierende Anschauungen über die Regulation der Ovulation werden auf der Basis der in dieser Untersuchungsreihe beobachteten chronologischen Beziehungen cyclischer Hormonschwankungen im Serum diskutiert. Die Analyse der Hormonkonzentrationen im Serum während der Cyclen mit Corpus-luteum-Insuffizienz stützt die Auffassung, daß dieser Funktionsstörung eine ungenügende Stimulation des heranreifenden Follikels zugrunde liegt. Andere kausale Faktoren müssen jedoch ebenfalls in Betracht gezogen werden.

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Authors and Affiliations

  1. Abteilung für Gynäkologische Endokrinologie, der Universitäts-Frauenklinik Bonn-Venusberg, Bonn-Venusberg

    G. Leyendecker, K. Hinckers, W. Nocke & E. J. Plotz

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  1. G. Leyendecker
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  2. K. Hinckers
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  3. W. Nocke
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  4. E. J. Plotz
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Additional information

Mit Unterstützung der Deutschen Forschungsgemeinschaft (No 67/1; No 67/3; Pl 2/6-7.503)

Fräulein Roswitha Klasen, Fräulein Bärbel Leffek und Herrn Eberhard Jost wird für die unermüdliche technische Mitarbeit gedankt.

Immunoreagenzien wurden von den National Institutes of Health (Bethesda, Md.) und dem Medical Research Council (London) zur Verfügung gestellt.

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Leyendecker, G., Hinckers, K., Nocke, W. et al. Hypophysäre Gonadotropine und ovarielle Steroide im Serum während des normalen menstruellen Cyclus und bei Corpus-luteum-Insuffizienz. Arch. Gynak. 218, 47–64 (1975). https://doi.org/10.1007/BF00672283

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  • DOI: https://doi.org/10.1007/BF00672283

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